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Autor:
Nagarkar, Radhika P.1, Hule, Rohan A.2, Pochan, Darrin J.2 pochan@udel.edu, Schneider, Joel P.1 schneijp@udel.edu
Publikováno v:
Journal of the American Chemical Society. 4/2/2008, Vol. 130 Issue 13, p4466-4474. 9p. 8 Graphs.
Publikováno v:
Journal of the American Chemical Society. 139(11)
The C-terminal selective electrophilic activation of polypeptides is essential for site-specific peptide modification and conjugation techniques such as Native Chemical Ligation (NCL). Peptide C-terminal α-thioesters are particularly valuable precur