Zobrazeno 1 - 10
of 23
pro vyhledávání: '"35"'
Autor:
Christopher M. Lauderback, David Allan Butterfield, Jaroslaw Kanski, Marina V. Aksenova, Sridhar Varadarajan
Publikováno v:
Journal of the American Chemical Society. 123(24)
Oxidative stress induced by amyloid beta-peptide (A beta) has been implicated in the neurodegeneration observed in Alzheimer's disease (AD) brain. However, the mechanism by which the predominant form of A beta found in AD brains, A beta(1--42), cause
Autor:
Dominique Florentin, Michel Azoulay, Jean-Claude Tabet, Georges Guillerm, François Frappier, Andrée Marquet
Publikováno v:
Journal of the American Chemical Society. 115:2139-2145
Previous results led to the conclusion that the last step of biotin biosynthesis, the sulfuur insertion into dethiobiotin should involve a thiol as intermediate. The three possible thiols have been synthesized and their biological activity was evalua
Autor:
Clive Yik-Sham Chung, Pei Liu, Kevin J. Bruemmer, Evan W. Miller, Christopher J. Chang, Kaoru Saijo, Yuki Nishikawa, Sumin Lee, Itaru Hamachi, Laura Craciun
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 35
J Am Chem Soc
J Am Chem Soc
Copper is a required nutrient for life and particularly important to the brain and central nervous system. Indeed, copper redox activity is essential to maintaining normal physiological responses spanning neural signaling to metabolism, but at the sa
Publikováno v:
Journal of the American Chemical Society. 141:3258-3264
Birefringent materials, the key components in modulating the polarization of light, are of great importance in optical communication and the laser industry. Limited by their transparency range, few birefringent materials can be practically used in th
Autor:
Nicolas Winssinger, Stefan Matile, Giuseppe Resnati, Naomi Sakai, Pierangelo Metrangolo, Kaori Fujisawa, Jacques Saarbach, Paola Morelli, Nicolas Chuard
Publikováno v:
Journal of the American Chemical Society, Vol. 138, No 35 (2016) pp. 11264-11271
Journal of the American Chemical Society
Journal of the American Chemical Society
In this report, we elaborate on two new concepts to activate arginine-rich cell-penetrating peptides (CPPs). Early on, we have argued that repulsion-driven ion-pairing interactions with anionic lipids account for their ability to move across hydropho
Publikováno v:
Journal of the American Chemical Society. 140(44)
Liquid fluoride thorium reactors have been considered as replacements for uranium-based nuclear reactors, having many economic and environmental advantages. The production of thorium is usually accompanied by the separation of thorium from rare earth
Autor:
Lingyang Zhu, Karena W. Chapman, Andrew A. Gewirth, Kimberly A. See, Olaf J. Borkiewicz, Peter J. Chupas, Christopher J. Barile, Kamila M. Wiaderek
Publikováno v:
Journal of the American Chemical Society. 138:328-337
Mg batteries are an attractive alternative to Li-based energy storage due to the possibility of higher volumetric capacities with the added advantage of using sustainable materials. A promising emerging electrolyte for Mg batteries is the magnesium a
Autor:
Elodie Point, Karine Moncoq, Marina Casiraghi, Ewen Lescop, Jean-Louis Banères, Marjorie Damian, Daniel Lévy, Eric Guittet, Nelly Morellet, Laurent Catoire, Jacky Marie
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩
International audience; Mapping the conformational landscape of G protein-coupled receptors (GPCRs), and in particular how this landscape is modulated by the membrane environment, is required to gain a clear picture of how signaling proceeds. To this
Autor:
Michal Avital-Shmilovici, Kalyaneswar Mandal, Nelson B. Phillips, Michael A. Weiss, Zachary P. Gates, Stephen B. H. Kent
Publikováno v:
Journal of the American Chemical Society. 135:3173-3185
Efficient total synthesis of insulin is important to enable the application of medicinal chemistry to the optimization of the properties of this important protein molecule. Recently we described "ester insulin"--a novel form of insulin in which the f
Publikováno v:
Journal of the American Chemical Society. 133:18420-18432
Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides using a diferric tyrosyl radical (Y(122)(•)) cofactor in β2 to initiate catalysis in α2. Each turnover requires revers