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Autor:
Shelton PM; Department of Chemistry, University of Washington , Seattle, Washington 98195, United States., Weller CE; Department of Chemistry, University of Washington , Seattle, Washington 98195, United States., Chatterjee C; Department of Chemistry, University of Washington , Seattle, Washington 98195, United States.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2017 Mar 22; Vol. 139 (11), pp. 3946-3949. Date of Electronic Publication: 2017 Mar 09.
Publikováno v:
Journal of the American Chemical Society. 139(11)
The C-terminal selective electrophilic activation of polypeptides is essential for site-specific peptide modification and conjugation techniques such as Native Chemical Ligation (NCL). Peptide C-terminal α-thioesters are particularly valuable precur