Zobrazeno 1 - 10
of 13
pro vyhledávání: '"35"'
Autor:
K. Kasdorf, Anthony G. M. Barrett
Publikováno v:
Journal of the American Chemical Society. 118:11030-11037
Quatercyclopropane 31 was oxidized, homologated, reduced, and monocyclopropanated to provide the pentacyclopropane alcohol 35. Subsequent deoxygenation of alcohol 35 was effected using N-(phenylthio)succinimide (24) and tributylphosphine followed by
Publikováno v:
Journal of the American Chemical Society. 119:12014-12015
Many of the acetogenins isolated from the Annonaceae plants1 have shown remarkable cytotoxic, antitumor, antimalarial, immunosuppressive, pesticidal, and antifeedant activities.2 Classification of these fatty acid derivatives into three subgroups is
Publikováno v:
Journal of the American Chemical Society. 138(22)
Circular bacteriocins, ranging from 35 to 70 amino acids, are the largest cyclic peptides produced by lactic acid bacteria to suppress growth of other bacteria. Their end-to-end cyclized backbone that enhances molecular stability is an advantage to s
Autor:
David C. Dorn, Kai Da Wu, Christoph Gaul, Dandan Shan, Xin-Yun Huang, Jon T. Njardarson, William P. Tong, Malcolm A.S. Moore, Samuel J. Danishefsky
Publikováno v:
Journal of the American Chemical Society. 126:11326-11337
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has been accomplished. Our concise and flexible approach utilized a Lewis acid-catalyzed diene aldehyde condensation (LACDAC) to
Publikováno v:
Journal of the American Chemical Society. 122:619-631
A stereoselective total synthesis of natural levorotatory polycavernoside A (1) has been achieved. Initial investigations produced the properly activated disaccharide unit 18b via the conjoining of building blocks originating from l-fucose and d-xylo
Autor:
Kenneth G. Hull, Gregory K. Friestad, Makoto Iwashima, Amos B. Smith, Emmanuel Bertounesque, Jingwu Duan, Brian A. Salvatore, Joseph Barbosa, and P. Grant Spoors, Yuping Qiu
Publikováno v:
Journal of the American Chemical Society. 121:10468-10477
An asymmetric synthesis of the stereochemically fully endowed C(9−25) spiroketal fragment (+)-BC of the calyculins (1−8) is described. Highlights of the synthesis include: a highly diastereoselective IBr-induced iodocarbonate cyclization to intro
Publikováno v:
Journal of the American Chemical Society. 121:700-709
Enantioselective total syntheses of aloperine (1), N-methylaloperine (2), and N-allylaloperine (3) are reported. The central element of the synthetic strategy is an intramolecular Diels−Alder reaction in which the cycloaddends are tethered by a N-s
Publikováno v:
Journal of the American Chemical Society. 119:12159-12169
The synthesis of (−)-stipiamide (1) is reported together with the designed enynes 2 (6,7-dehydrostipiamide) and 3 that are now shown to reverse the multidrug resistance (MDR) of human breast cancer cells (MCF-7adrR). Stipiamide was assembled using
Publikováno v:
Journal of the American Chemical Society. 119:9662-9671
A practical route for the total synthesis of 8,9-secokaurene diterpenes is described. The central step is the [3.3]sigmatropic rearrangement of spirocyclic intermediates such as 35, 40, and 41. All three compounds must necessarily respond identically
Autor:
J. Hu, Marvin J. Miller
Publikováno v:
Journal of the American Chemical Society. 119:3462-3468
A general total synthesis of mycobactins, represented by a mycobactin S, was achieved by a convergent approach. Two hydroxamic acid residues, 28 and 40b, were prepared from commercially available Nα-Cbz-l-lysine via dimethyldioxirane oxidations. Cyc