Zobrazeno 51 - 60
of 121
pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society. 127:15983-15988
There is a discrepancy between the observed and calculated stability of trans-cycloheptene (t-CHP). Generation of t-CHP has always led to its low-temperature (-40 degrees C) isomerization to cis-cycloheptene (c-CHP). However, force field and semiempi
Publikováno v:
Journal of the American Chemical Society. 127:11727-11735
Combinatorial libraries of non-biological polymers and drug-like peptides could in principle be synthesized from unnatural amino acids by exploiting the broad substrate specificity of the ribosome. The ribosomal synthesis of such libraries would allo
Publikováno v:
Journal of the American Chemical Society. 127:4659-4667
Current models assume that RNA folding is strongly hierarchical such that the base-paired secondary structure is more stable than and forms independently of the tertiary structure. This model has been difficult to test due to the experimental inabili
Autor:
Hyosun Lee, Heon Yong Kwon, Hoseop Yun, Su Yeon Lee, Young-Whan Park, Sung Jae Na, Song-I Han, Bun Yeoul Lee
Publikováno v:
Journal of the American Chemical Society. 127:3031-3037
Acyclic o-phenylene-bridged bis(anilido-aldimine) compounds, o-C(6)H(4){C(6)H(2)R(2)N=CH-C(6)H(4)-(H)N(C(6)H(3)R'(2))}(2) and related 30-membered macrocyclic compounds, o-C(6)H(4){C(6)H(2)R'(2)N=CH-C(6)H(4)-(H)N-C(6)H(2)R(2)}(2) (o-C(6)H(4)) are prep
Autor:
David C. Dorn, Kai Da Wu, Christoph Gaul, Dandan Shan, Xin-Yun Huang, Jon T. Njardarson, William P. Tong, Malcolm A.S. Moore, Samuel J. Danishefsky
Publikováno v:
Journal of the American Chemical Society. 126:11326-11337
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has been accomplished. Our concise and flexible approach utilized a Lewis acid-catalyzed diene aldehyde condensation (LACDAC) to
Autor:
Peter E. Doan, Patricia C. Dos Santos, Hong-In Lee, Mikhail Laryukhin, Brian M. Hoffman, Lance C. Seefeldt, Dennis R. Dean, Robert Y. Igarashi
Publikováno v:
Journal of the American Chemical Society. 126:9563-9569
Nitrogenase is the metalloenzyme that catalyzes the nucleotide-dependent reduction of N(2), as well as reduction of a variety of other triply bonded substrates, including the alkyne, acetylene. Substitution of the alpha-70(Val) residue in the nitroge
Publikováno v:
Journal of the American Chemical Society. 125:14728-14732
The description of reaction regulation in enzymes responsible for activating and catalyzing small molecules (O(2), NO) requires identification of ligand movement into the binding site and out of the enzyme through specific channels and docking sites.
Publikováno v:
Journal of the American Chemical Society. 122:8623-8630
Conformational preferences for the peptides SRPINATLAVEKEGSPVSITVNTTISA (H1) and APTMTRVLQGVLPALPQVVCNYR (H2) corresponding to the amino acid residues 9−35 and 38−60, respectively, of the glycoprot...
Publikováno v:
Journal of the American Chemical Society. 122:2749-2757
The ability of surfactant aggregate−H2O interfaces to control the regioselectivity of Diels−Alder reactions has been investigated. Cycloadditions of surfactant 1,3-dienes 2-[[3-(dimethyldodecylsilyl)-1,3-butadien-2-yl]thio]-N,N,N-trimethyl-1-etha
Publikováno v:
Journal of the American Chemical Society. 122:1008-1014
Tryptophan indole-lyase from Escherichia coli catalyzes the reversible cleavage of l-tryptophan to indole and ammonium pyruvate. This reaction is mechanistically interesting since it involves the elimination of an aromatic carbon leaving group. We ha