Zobrazeno 1 - 10
of 11
pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society. 113:7613-7630
A convergent asymmetric synthesis of the polyether antibiotic ferensimycin B has been completed. Chiral enolate bond constructions were employed to establish seven of the 16 stereocenters of the subunits 35 and 52, which comprise the C& and CI&3 port
Publikováno v:
Journal of the American Chemical Society. 119:12014-12015
Many of the acetogenins isolated from the Annonaceae plants1 have shown remarkable cytotoxic, antitumor, antimalarial, immunosuppressive, pesticidal, and antifeedant activities.2 Classification of these fatty acid derivatives into three subgroups is
Autor:
Michal Avital-Shmilovici, Kalyaneswar Mandal, Nelson B. Phillips, Michael A. Weiss, Zachary P. Gates, Stephen B. H. Kent
Publikováno v:
Journal of the American Chemical Society. 135:3173-3185
Efficient total synthesis of insulin is important to enable the application of medicinal chemistry to the optimization of the properties of this important protein molecule. Recently we described "ester insulin"--a novel form of insulin in which the f
Publikováno v:
Journal of the American Chemical Society. 138(22)
Circular bacteriocins, ranging from 35 to 70 amino acids, are the largest cyclic peptides produced by lactic acid bacteria to suppress growth of other bacteria. Their end-to-end cyclized backbone that enhances molecular stability is an advantage to s
Autor:
David C. Dorn, Kai Da Wu, Christoph Gaul, Dandan Shan, Xin-Yun Huang, Jon T. Njardarson, William P. Tong, Malcolm A.S. Moore, Samuel J. Danishefsky
Publikováno v:
Journal of the American Chemical Society. 126:11326-11337
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has been accomplished. Our concise and flexible approach utilized a Lewis acid-catalyzed diene aldehyde condensation (LACDAC) to
Publikováno v:
Journal of the American Chemical Society. 122:619-631
A stereoselective total synthesis of natural levorotatory polycavernoside A (1) has been achieved. Initial investigations produced the properly activated disaccharide unit 18b via the conjoining of building blocks originating from l-fucose and d-xylo
Autor:
Kenneth G. Hull, Gregory K. Friestad, Makoto Iwashima, Amos B. Smith, Emmanuel Bertounesque, Jingwu Duan, Brian A. Salvatore, Joseph Barbosa, and P. Grant Spoors, Yuping Qiu
Publikováno v:
Journal of the American Chemical Society. 121:10468-10477
An asymmetric synthesis of the stereochemically fully endowed C(9−25) spiroketal fragment (+)-BC of the calyculins (1−8) is described. Highlights of the synthesis include: a highly diastereoselective IBr-induced iodocarbonate cyclization to intro
Publikováno v:
Journal of the American Chemical Society. 121:700-709
Enantioselective total syntheses of aloperine (1), N-methylaloperine (2), and N-allylaloperine (3) are reported. The central element of the synthetic strategy is an intramolecular Diels−Alder reaction in which the cycloaddends are tethered by a N-s
Publikováno v:
Journal of the American Chemical Society. 119:12159-12169
The synthesis of (−)-stipiamide (1) is reported together with the designed enynes 2 (6,7-dehydrostipiamide) and 3 that are now shown to reverse the multidrug resistance (MDR) of human breast cancer cells (MCF-7adrR). Stipiamide was assembled using
Publikováno v:
Journal of the American Chemical Society. 119:9662-9671
A practical route for the total synthesis of 8,9-secokaurene diterpenes is described. The central step is the [3.3]sigmatropic rearrangement of spirocyclic intermediates such as 35, 40, and 41. All three compounds must necessarily respond identically