Zobrazeno 1 - 10
of 11
pro vyhledávání: '"35"'
Autor:
Christopher M. Lauderback, David Allan Butterfield, Jaroslaw Kanski, Marina V. Aksenova, Sridhar Varadarajan
Publikováno v:
Journal of the American Chemical Society. 123(24)
Oxidative stress induced by amyloid beta-peptide (A beta) has been implicated in the neurodegeneration observed in Alzheimer's disease (AD) brain. However, the mechanism by which the predominant form of A beta found in AD brains, A beta(1--42), cause
Autor:
Brandon Q. Mercado, Scott J. Miller, Nadia C. Abascal, Eric K. Paulson, Anthony J. Metrano, Anna E. Hurtley
Publikováno v:
Journal of the American Chemical Society
X-ray crystallography has been applied to the structural analysis of a series of tetrapeptides that were previously assessed for catalytic activity in an atroposelective bromination reaction. Common to the series is a central Pro-Xaa sequence, where
Autor:
John F. Quinn, Michael R. Whittaker, Phillip J. Hogg, Paul Wilson, Thomas P. Davis, Kristian Kempe, Sarah Mann, Athina Anastasaki, Angus P. R. Johnston, David M. Haddleton, Matthew R. Owen
Publikováno v:
Journal of the American Chemical Society. 137:4215-4222
The entropy-driven affinity of trivalent (in)organic arsenicals for closely spaced dithiols has been exploited to develop a novel route to peptide/protein-polymer conjugation. A trivalent arsenous acid (As(III)) derivative (1) obtained from p-arsanil
Publikováno v:
Journal of the American Chemical Society. 139(11)
The C-terminal selective electrophilic activation of polypeptides is essential for site-specific peptide modification and conjugation techniques such as Native Chemical Ligation (NCL). Peptide C-terminal α-thioesters are particularly valuable precur
Autor:
Michal Avital-Shmilovici, Kalyaneswar Mandal, Nelson B. Phillips, Michael A. Weiss, Zachary P. Gates, Stephen B. H. Kent
Publikováno v:
Journal of the American Chemical Society. 135:3173-3185
Efficient total synthesis of insulin is important to enable the application of medicinal chemistry to the optimization of the properties of this important protein molecule. Recently we described "ester insulin"--a novel form of insulin in which the f
Publikováno v:
Journal of the American Chemical Society. 130:4466-4474
De novo designed peptides, capable of undergoing a thermally triggered beta-strand-swapped self-assembly event leading to hydrogel formation were prepared. Strand-swapping peptide 1 (SSP1) incorporates an exchangeable beta-strand domain composed of e
Publikováno v:
Journal of the American Chemical Society. 127:11727-11735
Combinatorial libraries of non-biological polymers and drug-like peptides could in principle be synthesized from unnatural amino acids by exploiting the broad substrate specificity of the ribosome. The ribosomal synthesis of such libraries would allo
Publikováno v:
Journal of the American Chemical Society. 122:8623-8630
Conformational preferences for the peptides SRPINATLAVEKEGSPVSITVNTTISA (H1) and APTMTRVLQGVLPALPQVVCNYR (H2) corresponding to the amino acid residues 9−35 and 38−60, respectively, of the glycoprot...
Publikováno v:
Journal of the American Chemical Society. 120:1124-1132
A disulfide-bridged two-stranded α-helical coiled-coil peptide has been designed which undergoes a random coil to α-helical transition at pH 7 and 20 °C upon metal binding to two sites engineered into the molecule. The metal binding coiled-coil, d
Autor:
Frank Guarnieri, Harel Weinstein
Publikováno v:
Journal of the American Chemical Society. 118:5580-5589
The application of a recently developed technique of conformational memories (Guarnieri, F.; Wilson, S. R. J. Comput. Chem. 1995, 16, 5, 648) to the study of peptide structure is illustrated with an analysis of the conformational populations of the d