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pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society. 139:16657-16665
Ribonucleotide reductases (RNR) catalyze the reduction of nucleotides to deoxynucleotides through a mechanism involving an essential cysteine based thiyl radical. In the E. coli class 1a RNR the thiyl radical (C439•) is a transient species generate
Autor:
Martin J. Stillman, Thanh T. Ngu
Publikováno v:
Journal of the American Chemical Society. 128:12473-12483
The number of reported cases of chronic arsenic poisoning is on the rise throughout the world, making the study of the long-term effects of arsenic critical. As(3+) binds readily to biological thiols, including mammalian metallothionein (MT), which i
Publikováno v:
Journal of the American Chemical Society
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. Active E. coli class Ia RNR is an α2β2 complex that undergoes reversible, long-range proton-coupled electron transfer (PCET) over a pathwa
Publikováno v:
Journal of the American Chemical Society. 127:4659-4667
Current models assume that RNA folding is strongly hierarchical such that the base-paired secondary structure is more stable than and forms independently of the tertiary structure. This model has been difficult to test due to the experimental inabili
Autor:
Jerome A. Berson, Helen S. M. Lu
Publikováno v:
Journal of the American Chemical Society. 119:1428-1438
Methods are described for the synthesis of bis-diazene precursors of catenated tetraradicals. Photodeazetation in a low-temperature matrix of the N-tosylpyrrole member of the series (13) gives mainly the monodeazetated biradical 34, which is characte
Autor:
Takao Saito, Kiyoto Hori, Noboru Sayo, Noriyoshi Arai, Kazuhiko Hiratsuka-shi Matsumura, Takeshi Ohkuma
Publikováno v:
Journal of the American Chemical Society. 133(28)
A novel ruthenabicyclic complex with base shows excellent catalytic activity in the asymmetric hydrogenation of ketones. The turnover frequency of the hydrogenation of acetophenone reaches about 35 000 min–1 in the best case, affording 1-phenyletha
Publikováno v:
Journal of the American Chemical Society. 132(43)
Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides and requires a diferric-tyrosyl radical (Y(•)) cofactor to initiate catalysis. The initiation process requires long-rang
Publikováno v:
Journal of the American Chemical Society. 128:2522-2523
E. coli ribonucleotide reductase (RNR), composed of the homodimeric subunits alpha2 and beta2, catalyzes the conversion of nucleotides to deoxynucleotides via complex radical chemistry. The radical initiation process involves a putative proton-couple
Publikováno v:
Journal of the American Chemical Society. 109:1916-1920
The one-electron reduction of Cr"'(EDTA)at a mercury electrode was studied by an AC impedance technique in aqueous solutions of different viscosities (varied by addition of sucrose). The standard rate constant of the heterogeneous electron transfer,