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pro vyhledávání: '"35"'
Publikováno v:
Journal of the American Chemical Society, 125(35), 10570-10579. AMER CHEMICAL SOC
The binding of a series of p-alkylbenzamidinium chloride inhibitors to the serine proteinase trypsin over a range of temperatures has been studied using isothermal titration (micro)calorimetry and molecular dynamics simulation techniques. The inhibit
Publikováno v:
Journal of the American Chemical Society. 135(30)
The ultrafast dynamics in the interior of planar aligned multibilayers of 1,2-dilauroyl-sn-glycero-3-phosphocholine (dilauroylphosphatidylcholine, DLPC) are investigated using 2D IR vibrational echo spectroscopy. The nonpolar and water insoluble vibr
Publikováno v:
Journal of the American Chemical Society. 131(3)
Unlike most ordered molecular systems, globular proteins exhibit a temperature of maximum stability, implying that the structure can be disrupted by cooling. This cold denaturation phenomenon is usually linked to the temperature-dependent hydrophobic
Publikováno v:
Journal of the American Chemical Society. 129(10)
In this paper, we present a series of heteronuclear NMR experiments for the direct observation and characterization of lysine NH3 groups in proteins. In the context of the HoxD9 homeodomain bound specifically to DNA we were able to directly observe t
Publikováno v:
Journal of the American Chemical Society. 124(30)
The yields of gamma-radiation-induced single- and double-strand breaks (ssb's and dsb's) as well as base lesions, which are converted into detectable ssb by the base excision repair enzymes endonuclease III (Nth) and formamidopyrimidine-DNA glycosyla
Publikováno v:
Journal of the American Chemical Society. 124(11)
Despite the current availability of several crystal structures of purple acid phosphatases, to date there is no direct evidence for solvent-derived ligands occupying terminal positions in the active enzyme. This is of central importance, because cata
Publikováno v:
Journal of the American Chemical Society. 123(3)
We have characterized, for the first time, motional modes of a protein dissolved in supercooled water: the flipping kinetics of phenylalanyl and tyrosinyl rings of the 6 kDa protein BPTI have been investigated by NMR at temperatures between -3 and -1
Autor:
Yi Lu, Juewen Liu
Publikováno v:
Journal of the American Chemical Society. 129:9838-9839
Copper is a key metal ion both in environment monitoring and in biology, and exposure to high concentration of copper can cause adverse health effects. Although significant progresses have been made in designing fluorescent sensors for diamagnetic me
Publikováno v:
Journal of the American Chemical Society, 123(35), 8638-8639. AMER CHEMICAL SOC
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The self-aggregation of lipid molecules to form bilayer membranes is a process fundamental to the organization of life. Although qualitatively explained by the hydrophobic effect, 1 the molecular aggregation itself is a complex phenomenon that has no