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pro vyhledávání: '"Chen Liang"'
Publikováno v:
Journal of the American Chemical Society
Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the m
Publikováno v:
Journal of the American Chemical Society. 136:15146-15149
In contrast to an expected Ostwald-like ripening of amyloid assemblies, the nucleating core of the Dutch mutant of the Aβ peptide of Alzheimer's disease assembles through a series of conformational transitions. Structural characterization of the int