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Autor:
Smoukov SK; Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA., Telser J, Bernat BA, Rife CL, Armstrong RN, Hoffman BM
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2002 Mar 13; Vol. 124 (10), pp. 2318-26.
Autor:
Richard N. Armstrong, Christopher L. Rife, Stoyan K. Smoukov, Joshua Telser, Brian M. Hoffman, Bryan A Bernat
Publikováno v:
Journal of the American Chemical Society. 124(10)
FosA is a manganese metalloglutathione transferase that confers resistance to the broad-spectrum antibiotic fosfomycin, (1R,2S)-epoxypropylphosphonic acid. The reaction catalyzed by FosA involves the attack by glutathione on fosfomycin to yield the p