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Autor:
David C. Dorn, Kai Da Wu, Christoph Gaul, Dandan Shan, Xin-Yun Huang, Jon T. Njardarson, William P. Tong, Malcolm A.S. Moore, Samuel J. Danishefsky
Publikováno v:
Journal of the American Chemical Society. 126:11326-11337
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has been accomplished. Our concise and flexible approach utilized a Lewis acid-catalyzed diene aldehyde condensation (LACDAC) to