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Autor:
Dix AV; Laboratory of Bioorganic Chemistry, NIDDK, ‡Laboratory of Biochemistry and Genetics, NIDDK, and §Laboratory of Cell Biology, CCR, NCI, National Institutes of Health , Bethesda, Maryland 20892, United States., Moss SM, Phan K, Hoppe T, Paoletta S, Kozma E, Gao ZG, Durell SR, Jacobson KA, Appella DH
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2014 Sep 03; Vol. 136 (35), pp. 12296-303. Date of Electronic Publication: 2014 Aug 25.
Autor:
Travis Hoppe, Zhan-Guo Gao, Steven M. Moss, Khai Phan, Daniel H. Appella, Silvia Paoletta, Andrew V. Dix, Stewart R. Durell, Kenneth A. Jacobson, Eszter Kozma
Publikováno v:
Journal of the American Chemical Society
A programmable ligand display system can be used to dissect the multivalent effects of ligand binding to a membrane receptor. An antagonist of the A2A adenosine receptor, a G-protein-coupled receptor that is a drug target for neurodegenerative condit