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pro vyhledávání: '"35"'
Publikováno v:
J Am Chem Soc
Huntingtin polypeptides (htt(ex1)), encoded by exon 1 of the htt gene and containing an expanded polyglutamine tract, form fibrils that accumulate within neuronal inclusion bodies, resulting in the fatal neurodegenerative condition known as Huntingto
Autor:
Di Kang, Kevin W. Plaxco, Demosthenes P. Morales, Sheng Sun, Frederick W. Dahlquist, Martin Kurnik
Publikováno v:
Journal of the American Chemical Society, vol 139, iss 35
Here we demonstrate a new class of reagentless, single-step sensors for monitoring protein-protein and protein-peptide interactions that is the electrochemical analog of fluorescence polarization (fluorescence anisotropy), a versatile optical approac
Autor:
Nicolas Winssinger, Stefan Matile, Giuseppe Resnati, Naomi Sakai, Pierangelo Metrangolo, Kaori Fujisawa, Jacques Saarbach, Paola Morelli, Nicolas Chuard
Publikováno v:
Journal of the American Chemical Society, Vol. 138, No 35 (2016) pp. 11264-11271
Journal of the American Chemical Society
Journal of the American Chemical Society
In this report, we elaborate on two new concepts to activate arginine-rich cell-penetrating peptides (CPPs). Early on, we have argued that repulsion-driven ion-pairing interactions with anionic lipids account for their ability to move across hydropho
Autor:
Elodie Point, Karine Moncoq, Marina Casiraghi, Ewen Lescop, Jean-Louis Banères, Marjorie Damian, Daniel Lévy, Eric Guittet, Nelly Morellet, Laurent Catoire, Jacky Marie
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩
International audience; Mapping the conformational landscape of G protein-coupled receptors (GPCRs), and in particular how this landscape is modulated by the membrane environment, is required to gain a clear picture of how signaling proceeds. To this
Publikováno v:
ResearcherID
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2001, 123 (38), pp.9227-9234. ⟨10.1021/ja015867r⟩
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2001, 123 (38), pp.9227-9234. ⟨10.1021/ja015867r⟩
The size of condensed DNA particles is a key determinant for in vivo diffusion and gene delivery to cells. Gene molecules can be individually compacted by cationic thiol detergents into nanometric particles that are stabilized by oxidative conversion