Zobrazeno 1 - 10
of 12
pro vyhledávání: '"35"'
Autor:
Clive Yik-Sham Chung, Pei Liu, Kevin J. Bruemmer, Evan W. Miller, Christopher J. Chang, Kaoru Saijo, Yuki Nishikawa, Sumin Lee, Itaru Hamachi, Laura Craciun
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 35
J Am Chem Soc
J Am Chem Soc
Copper is a required nutrient for life and particularly important to the brain and central nervous system. Indeed, copper redox activity is essential to maintaining normal physiological responses spanning neural signaling to metabolism, but at the sa
Publikováno v:
Journal of the American Chemical Society. 141:10821-10829
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′−5′ exonuclease site (exo) for proofreading. Although separated by 35 Å, coordination between the pol and exo sites is
Autor:
Christian Hoppmann, Caiyun Fu, Roshanak Irannejad, Tomonori Kobayashi, Bing Yang, Lei Wang, Nanxi Wang
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 35
Acidic vesicles and organelles play fundamental roles in a broad range of cellular events such as endocytosis, lysosomal degradation, synaptic transmission, pathogen fate, and drug delivery. Fluorescent reporters will be invaluable for studying these
Autor:
Peyman Z. Moghadam, Marcus Fantham, Joseph T. Hupp, David Fairen-Jimenez, Timothy C. Wang, Michelle H. Teplensky, Peng Li, Joshua P. Mehta, Clemens F. Kaminski, Omar K. Farha, Laurence J. Young
Publikováno v:
Journal of the American Chemical Society. 139:7522-7532
Utilizing metal-organic frameworks (MOFs) as a biological carrier can lower the amount of the active pharmaceutical ingredient (API) required in cancer treatments to provide a more efficacious therapy. In this work, we have developed a temperature tr
Autor:
Nicolas Winssinger, Stefan Matile, Giuseppe Resnati, Naomi Sakai, Pierangelo Metrangolo, Kaori Fujisawa, Jacques Saarbach, Paola Morelli, Nicolas Chuard
Publikováno v:
Journal of the American Chemical Society, Vol. 138, No 35 (2016) pp. 11264-11271
Journal of the American Chemical Society
Journal of the American Chemical Society
In this report, we elaborate on two new concepts to activate arginine-rich cell-penetrating peptides (CPPs). Early on, we have argued that repulsion-driven ion-pairing interactions with anionic lipids account for their ability to move across hydropho
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2014, 136 (35), pp.12283-12295. ⟨10.1021/ja504063c⟩
Journal of the American Chemical Society, American Chemical Society, 2014, 136 (35), pp.12283-12295. ⟨10.1021/ja504063c⟩
International audience; Metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain bioorthogonal functionalities and enable the direct visualization and identification of glycoproteins from living cells. Each M
Autor:
Travis Hoppe, Zhan-Guo Gao, Steven M. Moss, Khai Phan, Daniel H. Appella, Silvia Paoletta, Andrew V. Dix, Stewart R. Durell, Kenneth A. Jacobson, Eszter Kozma
Publikováno v:
Journal of the American Chemical Society
A programmable ligand display system can be used to dissect the multivalent effects of ligand binding to a membrane receptor. An antagonist of the A2A adenosine receptor, a G-protein-coupled receptor that is a drug target for neurodegenerative condit
Publikováno v:
Journal of the American Chemical Society. 133:19807-19815
S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the act
Autor:
Katsunori Tsuboi, Daniel A. Bachovchin, Benjamin F. Cravatt, Hugh Rosen, Anna E Speers, Virneliz Fernandez-Vega, Timothy P. Spicer, Peter Hodder
Publikováno v:
Journal of the American Chemical Society. 133:16605-16616
Glutathione S-transferases (GSTs) are a superfamily of enzymes that conjugate glutathione to a wide variety of both exogenous and endogenous compounds for biotransformation and/or removal. Glutathione S-tranferase omega 1 (GSTO1) is highly expressed
Autor:
Jost Göttert, Matuesz L. Hupert, Michael C. Murphy, Dimitris E. Nikitopoulos, Juan Feng, Paul I. Okagbare, André A. Adams, Donald Patterson, Robin L. McCarley, Steven A. Soper
Publikováno v:
Journal of the American Chemical Society. 130:8633-8641
A novel microfluidic device that can selectively and specifically isolate exceedingly small numbers of circulating tumor cells (CTCs) through a monoclonal antibody (mAB) mediated process by sampling large input volumes (/=1 mL) of whole blood directl