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Autor:
Audrey J. Lazenby, Chandrakanth Are, Lynette M. Smith, Michael G. Brattain, Premila D. Leiphrakpam
Publikováno v:
Journal of Surgical Oncology. 123:1764-1772
OBJECTIVES To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC). BACKGROUND Stathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling
Autor:
Maureen D. Moore, Rasa Zarnegar, Olivier Elemento, Thomas J. Fahey, Heng Liang, Akanksha Verma, Katherine D. Gray, Theresa Scognamiglio, Anna Aronova, Timothy M. Ullmann, Irene M. Min, Wei Li, Shujun Xia
Publikováno v:
Journal of Surgical Oncology. 118:1042-1049
Background and objectives Hurthle cell carcinoma (HCC) is an unusual and relatively rare type of differentiated thyroid cancer. Currently, cytologic analysis of fine-needle aspiration biopsy is limited in distinguishing benign Hurthle cell neoplasms
Publikováno v:
Journal of Surgical Oncology. 106:94-100
Background and Objectives The roles of thrombospondin-1 (THBS-1) in tumor growth and metastasis are complicated and its function as a cancer inhibitor or promoter remains controversial. This clinical study investigated the functional roles of THBS-1
Autor:
Hiroshi Inoue, Fumiaki Tanaka, Masaichi Ohira, Koshi Mimori, Masaki Mori, Kosei Hirakawa, Katsuya Sakashita, Kouichirou Tahara, Tetsuji Sawada
Publikováno v:
Journal of Surgical Oncology. 98:559-564
Background Prostasin is considered to have suppressive activities against tumor progression. The aim of this study was to clarify its clinical significance in gastric cancer. Methods Tumor and the corresponding normal samples were prepared from a tot
Autor:
Xing Zhang, Bao Hong Guo, Kai hong Huang, Wen Ting Liao, Li Bing Song, Mu Sheng Zeng, Jian-hua Liu, Xue xian Li, Yan Feng
Publikováno v:
Journal of Surgical Oncology. 97:267-272
Background and Objective The Bmi-1 gene is a transcriptional repressor involved in oncogenesis in various human cancers. Here, we examine Bmi-1 expression in gastric carcinoma (GC) and investigates whether its expression correlates with patient progn
Publikováno v:
Journal of Surgical Oncology. 97:439-444
Background and Objectives NF-κB, ubiquitin and proteasome have been shown be important factors in oncogenesis. The aim of this study was to determine whether NF-κB could be a sensitive biomarker for gastric carcinoma. Methods Tumor and adjacent muc
Autor:
Christopher D. Mann, G. Garcea, C. D. Sutton, David P. Berry, Margaret M. Manson, Helena Doucas, Christopher P. Neal
Publikováno v:
Journal of Surgical Oncology. 97:63-68
Background and Objectives Reactivation of the Notch signalling pathway occurs in a range of human malignancies. Previous research suggests that Notch3 is expressed in pancreatic adenocarcinomas, but neither cellular location nor association with clin
Publikováno v:
Journal of Surgical Oncology. 95:241-249
Background and Objectives Fractalkine is the only CX3C chemokine, and its receptor, CX3CR1, is expressed on NK cells, CD8+ T cells, monocytes, and dendritic cells (DC). Although studies have reported that fractalkine regulates the host immune respons
Autor:
Hiroyuki Uetake, Takehiro Arai, Junichi Kuramochi, Jiro Kumagai, Satoshi Ikeda, Kenichi Sugihara
Publikováno v:
Journal of Surgical Oncology. 94:155-160
Background and Objectives Peptidyl prolyl cis-trans isomerase (Pin1) isomerizes only phosphorylated serine or threonine residues preceding proline in certain proteins and affects the protein function. Pin1 interacts with many signaling pathways, incl
Autor:
Catherine Uzan, Emile Daraï, Christophe Poncelet, Charlotte Dufournet, Raffaèle Fauvet, Danièle Hugol
Publikováno v:
Journal of Surgical Oncology. 92:337-343
Background We examined the expression of apoptosis-related proteins in serous versus mucinous borderline ovarian tumours, in comparison with benign and malignant ovarian tumours. Materials and Methods Immunohistochemical expression of pro-apoptotic (