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Autor:
Benjamin Bochon, Karolina Bochon, Georgios Schoretsanitis, Ekkehard Haen, Gerhard Gründer, Christoph Hiemke, Michael Paulzen, Maxim Kuzin
Publikováno v:
Journal of Psychopharmacology. 35:273-278
Background: Knowledge regarding the impact of body composition measures on pharmacokinetics of antipsychotics is limited. Aims: Our aim was to investigate the impact of body weight and body mass index on clozapine pharmacokinetics using a therapeutic
Autor:
Nicola Filippini, Catherine J. Harmer, Rob D. Chapman, Anthony A. James, Phil J. Cowen, Lucy Wright, Susannah E. Murphy, Liliana Capitão
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of flu
Publikováno v:
J Psychopharmacol
Background: Fragile X syndrome, the most common inherited cause for intellectual disability, is associated with alterations in cholinergic among other neurotransmitter systems. This study investigated the effects of donepezil hydrochloride, a choline
Autor:
Jason Smucny, Jason R. Tregellas
Publikováno v:
Journal of Psychopharmacology. 31:801-811
Patients with schizophrenia self-administer nicotine at rates higher than is self-administered for any other psychiatric illness. Although the reasons are unclear, one hypothesis suggests that nicotine is a form of ‘self-medication’ in order to r
Publikováno v:
Journal of Psychopharmacology. 29:1070-1076
Most smokers who attempt to quit lapse within the first week and are ultimately unsuccessful in their quit attempt. Nicotine withdrawal exacerbates cognitive and attentional problems and may be one factor in smoking relapse. The startle reflex respon
Autor:
Isabel Sweetman, Maria Gudbrandsen, Sabine Landau, Nicholas Magill, Anthony S. David, Maxine X. Patel, Suzanne Law, Diana Rose, Robert J. Flanagan
Publikováno v:
Journal of Psychopharmacology. 29:933-942
Background: This study aimed to develop a clinically acceptable method of therapeutic drug monitoring (TDM) for olanzapine and risperidone and to evaluate the feasibility of its implementation. Method: A non-randomised study of inpatients from five M
Autor:
Susanne Englisch, Andreas Meyer-Lindenberg, Frederike Schirmbeck, Mathias Zink, Franziska Rausch, Christine Esslinger, Sarah Eifler
Publikováno v:
Journal of Psychopharmacology. 27:349-357
Indirect evidence supports the assumption that antiserotonergic second-generation antipsychotics (SGA) induce and aggravate obsessive–compulsive symptoms (OCS) in schizophrenia. However, multimodal studies assessing the long-term interaction of pha
Autor:
Gabriela Rosenblau, Meline Stoy, Andreas Heinz, Andreas Ströhle, Philipp Sterzer, Soyoung Q. Park, Eva Friedel, Michael Bauer, Maximilian Pilhatsch
Publikováno v:
Journal of Psychopharmacology. 26:1424-1433
Major Depressive Disorder (MDD) is associated with impaired processing and regulation of emotions. A vast body of research has elucidated the altered neural processes that occur in response to emotional stimuli, while little is known about anticipato
Publikováno v:
Journal of Psychopharmacology. 26:724-732
The objective of the present study was to examine the effect of long-term management of insulin resistance and hyperglycemia on neurobehavioral deficits in db/db mice. In this study, 5-week-old db/db and lean control mice were fed with rosiglitazone
Autor:
Mazda Adli, Andreas Ströhle, Meline Stoy, Claudia Hägele, Jana Wrase, Roland Ricken, Kristina Suchotzki, Michael Bauer, Andreas Heinz, Florian Schlagenhauf, Brian Knutson, Felix Bermpohl, Philipp Sterzer, Katharina Schmack
Publikováno v:
Journal of Psychopharmacology. 26:677-688
Major Depressive Disorder (MDD) involves deficits in the reward system. While neuroimaging studies have focused on affective stimulus processing, few investigations have directly addressed deficits in the anticipation of incentives. We examined neura