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Publikováno v:
Journal of Pharmacy and Pharmacology. 74:282-291
Objectives Myocardial I/R injury is one of the most serious complications after reperfusion therapy in patients with myocardial infarction. Remifentanil has been found to protect the heart against I/R injury. However, its underlying mechanism remains
Publikováno v:
Journal of Pharmacy and Pharmacology. 74:367-376
Objectives Cyclophosphamide (CPA) is highly effective in treating several human tumours and autoimmune disorders; but, it triggers deleterious side effects. Avocado, Persea americana (Mill.), is a widely consumed fruit with pronounced nutritional and
Autor:
Tugba Bal Tastan, Rustem Anil Ugan, Duygu Kose, Zekai Halici, Elif Cadirci, Harun Un, Aysenur Kahramanlar
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:1302-1309
Objectives We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically. Methods A total of 40 rats
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:835-845
Objectives Eugenosedin-A (Eu-A), an adrenergic and serotonergic antagonist, is known to have anti-metabolic syndrome effects. In this study, we evaluated its protective effects against diabetes mellitus (DM) in spontaneous hypertensive rats (SHR) and
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:901-915
Objectives The study was aimed to evaluate the potential of hydroalcoholic extract of Pinus roxburghii (PRE) stem bark in post-menopausal osteoporosis and its underlying mechanisms. Methods In silico docking of the markers was done using AutoDock ver
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:778-784
Objectives Dapagliflozin (Dapa) could potentially be used to treat type 1 diabetes mellitus. We tested the hypothesis that it would influence blood lipid levels and visceral fat accumulation in a rodent diabetic model. Methods We used three groups of
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:824-834
Objectives This study was aimed to investigate the effects of garlic oil (GO), an important natural constituent used in alleviating diabetes and its complications, on the expression levels of irisin and related genes. Methods Thirty-two rats were div
Autor:
Suzan M. Mansour, Reham A. Mohammed
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:310-321
Objectives Hydrogen sulfide (H2S) is a neuromodulator that plays a protective role in multiple neurodegenerative diseases including Alzheimer’s (AD) and Parkinson’s (PD). However, the precise mechanisms underlying its effects against Huntington
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:473-486
Objectives Anti-TB drugs-isoniazid and rifampicin induced hepatotoxicity present a significant clinical problem. We aimed to evaluate the beneficial effect of gallic acid in anti-TB drug-induced liver injury in vivo and for the mechanism of action, w
Autor:
Rania A Abd El-Aal, Weam W. Ibrahim, Noha F. Abdelkader, Dalia K Abdulwahab, Hekma A. Abdel-Latif
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:366-376
Objectives Reduced male fertility is highly prevalent with hypercholesterolaemia. Though statins are drugs of choice for hypercholesterolaemia, their effect on male fertility is still controversial and dose-dependent. Grape seed extract (GSE) possess