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Publikováno v:
Journal of Pharmacy and Pharmacology. 65:734-744
Objectives The aim of the study was to evaluate berberine-induced bidirectional regulation on the contractility of jejunum. Methods Different low and high contractile states of isolated jejunal segment from rat were established to investigate the eff
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:561-566
Objectives The semi-synthetic bile salt, 12-oxochenodeoxycholate (OCDC also known as 12-monoketocholate), has been shown to enhance drug permeation across biological membranes with low cytotoxicity. Its effect on the analgesic potency and brain conce
Autor:
Sachin S Kushare, Surendra G. Gattani
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:79-93
Objectives In oral absorption of a drug, the drug first dissolves and then is absorbed by diffusion through gastrointestinal membranes. The gastrointestinal environment is aqueous in nature and it is well-known that one-third of the drug population i
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:300-309
Objectives Previous studies have shown eugenosedin-A, a 5-HT1B/2A and α1/α2/β1-adrenergic blocker, is able to decrease cholesterol levels, hyperglycaemia and inflammation in hyperlipidaemic mice induced by high-fat diet (HFD). The aim of this stud
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:280-291
Objectives The effect of genistein, a natural soy isoflavone, on pharmacokinetics and intestinal toxicity, or late-onset diarrhoea, of irinotecan hydrochloride (CPT-11) was examined in rats. Methods Probenecid, a typical inhibitor of multidrug resist
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:243-252
Objectives To investigate the potential protective effects of captopril, the angiotensin-converting enzyme inhibitor, in diabetic rats exposed to ischaemia/reperfusion (I/R) renal injury. Methods Following successful induction of diabetes, captopril
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:149-155
Objectives With the growing popularity of herbal and natural medicinal products, attention has turned to possible interactions between these products and pharmaceutical drugs. In this study, we examined whether astragaloside IV (AGS-IV) could inhibit
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:123-132
Objectives Adenosine is known to induce a bronchospasm in asthma- and COPD patients. The role of A2B receptors was investigated with respect to several parameters of the respiratory tract: tonus of smooth muscle, ciliary beat frequency as measured by
Autor:
Pedro Marcos Gomes Soares, Emmanuel P. Souza, Ana Maria Sampaio Assreuy, Alana de Freitas Pires, David N. Criddle
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1777-1784
Objectives We evaluated the relaxant activity of the essential oil of Mentha pulegium L. (EOMP) and pulegone in rat isolated tracheal and bladder smooth muscles. Methods Isometric contractions of isolated tracheal and bladder strips from male Wistar
Autor:
Shraddha Rajak, Aditya Narasimha Murthy, Rahul Vats, Kanthikiran Varanasi, Rambabu Arla, Sridhar Veeraraghavan
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1638-1645
Objectives Atorvastatin (ATV) and cilostazol (CLZ) are often co-prescribed to treat conditions such as peripheral arterial disease. In the present study, the drug–drug interaction potential of multi-dose CLZ on both pharmacokinetics and the lipid-l