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Autor:
Michael W. Whitehouse, K D Rainsford
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:476-482
A slow-release zinc complex, zinc monoglycerolate (ZMG) was examined for its potential gastroprotective activity in various gastric ulcer models. These models comprised (a) oral or parenteral nonsteroidal anti-inflammatory drugs (NSAIDs) given to rat
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:421-424
The hypothermic action of the thiazoloazepine derivative B-HT 920, an α2-adrenoceptor agonist has been investigated in rats. B-HT 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)-azepine dihydrochloride) (0·25–10 mg kg−1 i.p.) induce
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:285-288
The administration of the 5-HT1A agonist 8-OH-DPAT (0.8 μmol kg−1 s.c. — 40 min) produced an increase in dopamine (DA) turnover, estimated by the quotient (DOPAC + HVA) DA−1, in the ventral striatum of the rat. No statistically significant eff
Publikováno v:
Journal of Pharmacy and Pharmacology. 32:701-704
In fasted rats 6-aminonicotinamide (6-AN) produced delayed hyperglycaemia, the peak effect being seen by 7 h. Fasting plasma insulin concentrations were not significantly altered but liver glycogen concentrations were decreased following treatment wi
Publikováno v:
Journal of Pharmacy and Pharmacology. 31:545-550
The effects of concentrations of ouabain on the isometric developed tension (IDT) of isolated left auricles driven at 0·4, 0·8 and 3·3 Hz, were explored. With 0·4 or 0·8 Hz, increasing concentrations of ouabain (3·4 or 6·8 times 10−6; 1·0;
Publikováno v:
Journal of Pharmacy and Pharmacology. 33:445-450
Water was chosen as the optimal medium for the extraction of tyrosine hydroxylase (TH) from rat brain. Determination of TH activity in crude homogenates failed to exhibit a linear relationship between enzyme concentration and measured activity, howev
Publikováno v:
Journal of Pharmacy and Pharmacology. 32:278-284
Bromocriptine and apomorphine produced identical circling responses in rodents with medial forebrain bundle lesions. Rotation induced by bromocriptine, but not by apomorphine, was inhibited by prior treatment with reserpine or α-methyl-p-tyrosine su
Publikováno v:
Journal of Pharmacy and Pharmacology. 36:608-613
24 h pretreatment with molindone enhanced the behavioural effects of l-dopa and 5-HTP, precursors of biogenic amines (catecholamines and 5-HT respectively) preferentially deaminated by MAO-A, confirming that a metabolite of molindone inhibits MAO-A.
Autor:
G K Kostopoulos, G G Yarbrough
Publikováno v:
Journal of Pharmacy and Pharmacology. 27:408-412
The effects of microiontophoretic applications of equivalent doses (ejection times and currents) of noradrenaline, amphetamine, octop-amine and p-hydroxynorephedrine on the spontaneous firing of Purkinje and unidentified cells in the cerebellum of ra
Autor:
C Braestrup
Publikováno v:
Journal of Pharmacy and Pharmacology. 29:463-470
Amphetamine-like stimulants were divided into two groups, one in which the stereotyped behaviour was not antagonized by reserpine [(+)-amphetamine, (-)-amphetamine, methamphetamine, phenmetrazine and phenethylamine] and another group in which the beh