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Publikováno v:
Journal of Pharmacy and Pharmacology. 43:421-424
The hypothermic action of the thiazoloazepine derivative B-HT 920, an α2-adrenoceptor agonist has been investigated in rats. B-HT 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)-azepine dihydrochloride) (0·25–10 mg kg−1 i.p.) induce
Publikováno v:
Journal of Pharmacy and Pharmacology. 33:445-450
Water was chosen as the optimal medium for the extraction of tyrosine hydroxylase (TH) from rat brain. Determination of TH activity in crude homogenates failed to exhibit a linear relationship between enzyme concentration and measured activity, howev
Autor:
S. O. A. Bamgbose, Mary O. Uguru
Publikováno v:
Journal of Pharmacy and Pharmacology. 38:140-143
The mechanism by which 5-HT produces relaxations of the rat caecum has been examined. Propranolol and cocaine markedly attenuated the relaxations whereas tetrodotoxin had no effect. Higher doses of propranolol and cocaine (>10−6 M), as well as rese
Autor:
S Garattini, A Jori
Publikováno v:
Journal of Pharmacy and Pharmacology. 17:480-488
Imipramine-like drugs potentiate the hyperthermic response obtained by infusion of noradrenaline, adrenaline and isoprenaline. In addition to this effect, desipramine increases the hyperthermic response induced by L-dopa (in monoamine oxidase blocked
Autor:
K. G. S. Bhatt, R. K. Sanyal
Publikováno v:
Journal of Pharmacy and Pharmacology. 16:385-393
During aseptic inflammation there is a rise in the histamine and 5-hydroxytryptamine (5-HT) contents of the skin and several internal organs in mice and rats. The time course of this rise has been worked out. Depletion of histamine or 5-HT, adversely
Publikováno v:
Journal of Pharmacy and Pharmacology. 15:798-803
The subcutaneous implantation of a cotton pellet in the rat evokes a short-lasting phase of increased capillary permeability lasting some 20 min. after implantation followed by a more sustained phase which occurs after 2·5–3 hr. The early increase
Autor:
Gy. Gál, G. Leszkovszky
Publikováno v:
Journal of Pharmacy and Pharmacology. 19:226-230
Isoprenaline hydrochloride in subcutaneous doses of 2 × 10 to 2 × 680 mg/kg caused histologically detectable, characteristic heart necroses. Pathological changes were dose-dependent. The degree of necrosis was assessed by a quantitative histologica
Autor:
Wadie T. Abed
Publikováno v:
Journal of Pharmacy and Pharmacology. 41:807-808
The thresholds for metrazol (pentylenetetrazol) clonic convulsions and brain γ-aminobutyric acid contents were significantly reduced after treatment with the monoamine depletors reserpine, tetrabenazine and p-chlorophenylalanine. Moreover, α-methyl