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Publikováno v:
Journal of Pharmacy and Pharmacology. 46:833-837
Oral administration of indobufen to male rats for three days at daily doses of 5, 10 and 20 mg kg−1 resulted in no changes in liver total glutathione, cytosolic glutathione S-transferases or microsomal epoxide hydrolase. Reduced glutathione appeare
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:306-310
Four kinin-releasing enzymes, trimucase I, II, III and IV, isolated from Trimeresurus mucrosquamatus venom (TMV) caused rat hind-paw swelling. Trimucase I and III were less potent than trimucase II and IV in this effect. Pretreatment with diphenhydra
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:857-860
An amino acid analyser method using ninhydrin was developed for (S)-α-fluoromethylhistidine (FMH) with a minimum quantitation limit of 0.2 μg mL−1. The assay was used to study the kinetics of FMH in rat. After bolus intravenous administration of
Publikováno v:
Journal of Pharmacy and Pharmacology. 37:545-549
FK-448 is a potent and specific inhibitor of chymotrypsin, which enhances the intestinal absorption of insulin in rats and dogs resulting in a decrease in blood glucose levels in these animals. In dogs, the immunoreactive insulin (IRI) level of plasm
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:333-336
The relationship between chemically induced glycogenolysis and decreased thiol content in the rat isolated, perfused liver has been examined. Chemicals such as 2,4-dinitrophenol (DNP), diethyl maleate, alchohols and anti-inflammatory agents (except f
Publikováno v:
Journal of Pharmacy and Pharmacology. 35:571-575
The effects on plasma lipids and nicotinic acid concentrations of a single dose of 2-(3-pyridinecarbonylamino)-2-deoxy-1,3,4,6 dihydrogen-D-glucose tetra-3-pyridinecarboxylate (LG 13979) compared with the effects of nicotinic acid and of its known de
Publikováno v:
Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 1985, 37, pp.751-754
Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 1985, 37, pp.751-754
Adult, male rats were infected with 20 metacercariae of Fasciola hepatica given orally, other rats were left untreated. Five weeks after infestation, some animals received phenobarbitone, 3-methylcholanthrene, β-naphthoflavone or Arochlor 1254, to i
Autor:
Bertil B. Fredholm, Bror Jonzon
Publikováno v:
Journal of Pharmacy and Pharmacology. 36:846-848
We have evaluated the proposal that adenosine may mediate some of the effects of tricyclic antidepressant therapy. In-vitro desipramine (DMI) (1–10 μm) did not affect adenosine or 2-chloroadenosine-induced inhibition of lipolysis or the adenosine
Autor:
Alberto Machado, Antonio Ayala
Publikováno v:
Journal of Pharmacy and Pharmacology. 39:551-552
The action of bezafibrate on fatty acid biosynthesis pathways has been examined in rat tissues. The drug abolished the induction of fatty acid synthesis that occurs on refeeding the animals with a high carbohydrate diet and by insulin administration
Autor:
O. J. Hodgson, R. G. L. Pullen
Publikováno v:
Journal of Pharmacy and Pharmacology. 39:863-864
Interest in the actions of the peptide cholecystokinin (CCK) has led to the design and synthesis of several non-peptide CCK antagonists, the most recent being that produced by Merck Sharp & Dohme and designated L-364, 718. This can be viewed as modif