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Publikováno v:
Journal of Pharmacy and Pharmacology. 72:1341-1351
Objectives Migraine is a neurological disorder with unilateral pulsatile headache which can affect the functions of sufferers. Migraineurs experience some undesirable symptoms such as pain, nausea, vomiting and in some cases auras which make the oral
Publikováno v:
Journal of Pharmacy and Pharmacology. 69:1447-1457
Objective This study was aimed to investigate the potential of formulated valproic acid-encapsulated nanoemulsion (VANE) to improve the brain bioavailability of valproic acid (VPA). Methods Valproic acid-encapsulated nanoemulsions were formulated and
Publikováno v:
Journal of Pharmacy and Pharmacology. 71:83-92
Objectives This study was conducted to explore whether Hypericum perforatum L. (HPL) as a potent antioxidant protects against oxidative stress, cytokine production and caspase expression in muscle (soleus), brain and blood of sciatic nerve injury (SN
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:561-566
Objectives The semi-synthetic bile salt, 12-oxochenodeoxycholate (OCDC also known as 12-monoketocholate), has been shown to enhance drug permeation across biological membranes with low cytotoxicity. Its effect on the analgesic potency and brain conce
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:869-874
Objective The present study was designed to observe the effects of 3,6′-disinapoyl sucrose (DISS), an active oligosaccharide ester component obtained from the roots of Polygala tenuifolia Willd., on behavioral and biochemical aspects of depression
Autor:
Shinji Kobuchi, Nobuyuki Sugioka, Yukako Ito, Masakazu Shibata, Keizo Fukushima, Kanji Takada
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:515-523
Objective This study was undertaken to investigate the effects of hyperlipidaemia on the pharmacokinetics of clomipramine, an antidepressant, particularly addressing the change of clomipramine distribution to plasma components in poloxamer 407-induce
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:261-266
Objective To evaluate the analgesic and anti-migraine activities of senkyunolide I from Ligusticum chuanxiong. Methods Mice were orally administered various doses of senkyunolide I, and their pain levels were assessed in a hot-plate test and by appli
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:669-675
Objectives The purpose of this study was to find out whether nasal application of buspirone could increase its bioavailability and directly transport the drug from nose to brain. Methods A nasal formulation (Bus-chitosan) was prepared by dissolving 1
Publikováno v:
Journal of Pharmacy and Pharmacology. 59:1733-1738
Huang-Lian-Jie-Du-Tang (HLJDT), an aqueous extract of Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Fructus Gardeniae (3:2:2:3) is an important multi-herb remedy in traditional Chinese medicine (TCM). The aim of this study was to eval
Publikováno v:
Journal of Pharmacy and Pharmacology. 59:935-940
Transferrin (Tf)-conjugated solid lipid nanoparticles (SLNs) were investigated for their ability to deliver quinine dihydrochloride to the brain, for the management of cerebral malaria. SLNs were prepared by an ethanol injection method using hydrogen