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Publikováno v:
Journal of Pharmacy and Pharmacology. 69:1513-1523
ObjectivesTo study the functional consequences of the human and rat forms of OCT2 in the presence of phenothiazines.MethodsMDCK cells expressing human or rat OCT2 were established, and MPP+ transport was determined by uptake assays. Concentration dep
Publikováno v:
Journal of Pharmacy and Pharmacology. 67:1457-1465
Objectives The objective of this study was to address the beneficial effects of Cistanche tubulosa extract on improving the low intestinal permeability of echinacoside (ECH) and acteoside (ACT). Methods Absorption of ECH and ACT in C. tubulosa extrac
Autor:
Chada Phisalaphong, Robert C. Hider, Zi Dong Lu, Yuanyuan Xie, Somdet Srichairatanakool, Suthat Fucharoen, Kanjana Pangjit, Ratana Banjerdpongchai
Publikováno v:
Journal of Pharmacy and Pharmacology. 67:703-713
Objectives Desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) are iron chelators currently in clinical use for the treatment of iron overload. Due to difficulties with administration and associated side effects with these three molecules,
Autor:
Masaki Otagiri, Keiichi Kawai, Hakaru Seo, Teruyuki Komatsu, Keishi Yamasaki, Toru Maruyama, Kazuaki Taguchi, Victor Tuan Giam Chuang, Yukino Urata, Makoto Anraku, Ryota Tanaka
Publikováno v:
Journal of Pharmacy and Pharmacology. 67:255-263
Objectives The half-life of fatty acid-conjugated antidiabetic drugs are prolonged through binding to albumin, but this may not occur in diabetic patients with nephropathy complicated with hypoalbuminemia. We previously showed that human serum albumi
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:988-994
Objectives Drug-induced kidney injury is a serious adverse event which needs to be monitored during aminoglycoside therapy. Urine cystatin C is considered an early and sensitive marker of nephrotoxicity. Cystatin C, a low-molecular-weight serum prote
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:300-309
Objectives Previous studies have shown eugenosedin-A, a 5-HT1B/2A and α1/α2/β1-adrenergic blocker, is able to decrease cholesterol levels, hyperglycaemia and inflammation in hyperlipidaemic mice induced by high-fat diet (HFD). The aim of this stud
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1445-1451
Objectives Glycyrrhetinic acid is the main metabolite of glycyrrhizin and the main active component of Licorice root. This study was designed to investigate the in-vitro metabolism of glycyrrhetinic acid by liver microsomes and to examine possible me
Autor:
Xue-Mei Qin, Xiaojie Liu, Jie Cui, Li-Zeng Zhang, Xiaoxia Gao, Guanhua Du, Hai-Feng Sun, Yu-Zhi Zhou, Zhenyu Li, Zhong-Feng Li
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:578-588
Objectives To investigate the antidepressant effects of Xiaoyaosan (XYS) in a chronic unpredictable mild stress (CUMS) depression model. Methods The changes in behaviour and plasma metabolic profiles were investigated after four-week CUMS exposure an
Autor:
Göksel Şener, Feriha Ercan, Tuğrul Çakır, Ender Dulundu, Emre Sener, Erkan Özkan, Ahmet Ozer Sehirli, Umit Topaloglu
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:1566-1571
Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats. Methods Following a single dose of methotrexate (2
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:1454-1461
Objectives Hexapeptide is a novel synthetic oligopeptide with a structure similar to that of eptifibatide. This study was designed to investigate the anticoagulant, anti-aggregation, disaggregation and anti-thrombogenesis effects of hexapeptide. Meth