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Publikováno v:
Journal of Pharmacy and Pharmacology. 64:1445-1451
Objectives Glycyrrhetinic acid is the main metabolite of glycyrrhizin and the main active component of Licorice root. This study was designed to investigate the in-vitro metabolism of glycyrrhetinic acid by liver microsomes and to examine possible me
Autor:
Xue-Mei Qin, Xiaojie Liu, Jie Cui, Li-Zeng Zhang, Xiaoxia Gao, Guanhua Du, Hai-Feng Sun, Yu-Zhi Zhou, Zhenyu Li, Zhong-Feng Li
Publikováno v:
Journal of Pharmacy and Pharmacology. 64:578-588
Objectives To investigate the antidepressant effects of Xiaoyaosan (XYS) in a chronic unpredictable mild stress (CUMS) depression model. Methods The changes in behaviour and plasma metabolic profiles were investigated after four-week CUMS exposure an
Publikováno v:
Journal of Pharmacy and Pharmacology. 49:743-746
The effect of anionic compounds on the hepatic uptake of paracetamol sulphate, a conjugative metabolite of paracetamol, has been studied. Hepatic uptake of paracetamol sulphate by isolated hepatocytes was inhibited by bromosulphophthalein, dibromosul
Publikováno v:
Journal of Pharmacy and Pharmacology. 47:768-774
The effects of KBT-3022 and its metabolite desethyl KBT-3022 on platelet aggregation were determined in rat, guinea-pig, rabbit and human platelets in-vitro and ex-vivo. KBT-3022 and desethyl KBT-3022 inhibited platelet aggregation induced by arachid
Autor:
Kurt Leander, Bill Martin, Marianne Nordqvist, Michael Binder, Stig Agurell, Jan-Erik Lindgren
Publikováno v:
Journal of Pharmacy and Pharmacology. 28:275-279
Cannabidiol (CBD) was metabolized in vitro by rat liver enzymes. Unchanged CBD and eight monohydroxylated metabolites were isolated and positively identified. As previously reported, 7-hydroxy-CBD was the major metabolite. The second most abundant me
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:388-391
The capacity of human, rabbit and rat liver microsomes and purified isozymes of cytochrome P450 to metabolize theophylline has been assessed. In all three species the 8-hydroxylation of theophylline to 1,3-dimethyluric acid (1,3-DMU) was the major pa
Publikováno v:
Journal of Pharmacy and Pharmacology. 30:415-418
Marked differences were observed, in the ability of fortified 9000 g liver homogenate supernatants from three species to reduce 1-phenyl-2-propanone to the corresponding alcohol. This metabolic keto-reduction was negligible in homogenates from the ra
Publikováno v:
Journal of Pharmacy and Pharmacology. 23:842-847
Seventeen h after the intraperitoneal administration of 33 mg/kg of [14C]mycophenolic acid to rats, radioactivity was bound to the tissues of the intestines, bladder, stomach, kidney, liver and lung in decreasing order; no binding to spleen tissue wa
Autor:
Peter A. Crooks, C S Godin
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:153-154
Incubation of human liver cytosol with either R-(+)-[3H-N′CH3]nicotine or S-(−)-[3H-N′CH3]nicotine results in the formation of the corresponding N-methyl quaternary ammonium metabolite. A substrate stereoselectivity was observed in that the tur
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:64-65
A simple fluorometric assay method as well as a sensitive HPLC method for determination of bunitrolol, a β-adrenoreceptor blocking drug, and its 4-hydroxylated metabolite is described. More than 90% of bunitrolol metabolized was accounted for by the