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Autor:
Margano Anginoni, Jaqueline Finau, Moacir Geraldo Pizzolatti, Cristina Setim Freitas, Adair R.S. Santos, Cristiane Hatsuko Baggio, Maria Consuelo Andrade Marques
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1105-1110
Baccharis illinita DC (Compositae) is used in folk medicine to treat gastric disturbances. Preliminary studies with other extracts of B. Illinita showed gastric protection against ethanol-, indometacin- and stress-induced ulcers and the inhibition of
Autor:
Kyoung Youl Lee, Sun Kyu Park, Seung-Chun Park, Hyo In Yun, Jong Hwan Lim, Man Hee Rhee, Sang Keun Kim, Hwa Jin Park, Jae Youl Cho, Sung Dae Kim
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:867-870
This study was designed to investigate the effect of surfactin C, which is derived from Bacillus subtilis, on platelet aggregation and homotypic leucocyte aggregation. Surfactin C strongly and dose-dependently inhibited platelet aggregation, which wa
Autor:
John T. Fell, Oluwatoyin A. Odeku
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:163-168
Khaya and albizia gums were evaluated as compression coatings for target drug delivery to the colon using indometacin (a water insoluble drug) and paracetamol (a water soluble drug) as model drugs. The core tablets were compression-coated with 300 an
Publikováno v:
Journal of Pharmacy and Pharmacology. 51:79-84
The reductive debromination of the hypnotic (α-bromoiso-valeryl)urea to (3-methylbutyryl)urea by intestinal bacteria has been studied. The caecal contents of rats, mice, hamsters, guinea-pigs and rabbits had significant debrominating activity toward
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:1185-1189
We have examined the 4-hydroxylation of bunitrolol in rabbit and rat liver microsomes. Significant species differences (rabbit < rat of both sexes) and sex (male > female of both species) were observed in the formation of 4-hydroxybunitrolol from rac
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:945-950
Three metabolizing systems (rat, heterologously expressed CYP3A4 and human liver) were used to evaluate 12 analogues of dapsone (4,4′diaminodiphenylsulphone) in-vitro. Methaemoglobin formation in a two-compartment and cytotoxicity in a single-compa
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:779-784
With microsomes prepared from a single human liver, 4,4′-diaminodiphenyl sulphone (DDS), 4-acetyl-4-aminodiphenyl sulphone (MADDS), 4-acetyl-4-aminodiphenyl thioether (MADDT) and 4,4′-diacetyldiphenyl thioether (DADDT) caused significantly greate
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:456-458
Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanoli
Publikováno v:
Journal of Pharmacy and Pharmacology. 40:388-391
The capacity of human, rabbit and rat liver microsomes and purified isozymes of cytochrome P450 to metabolize theophylline has been assessed. In all three species the 8-hydroxylation of theophylline to 1,3-dimethyluric acid (1,3-DMU) was the major pa
Autor:
Michael Murray
Publikováno v:
Journal of Pharmacy and Pharmacology. 38:472-475
The quinoline-based local anaesthetic cinchocaine (dibucaine) was found to be a mixed-type inhibitor of microsomal aminopyrine N-demethylase and 7-ethoxycoumarin O-deethylase activities from control and phenobarbitone-induced rat liver in-vitro. Cinc