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Autor:
Gen Ishikawa, Mikihiro Yoshie, Wakana Ohneda, Akihito Nakai, Eiichi Tachikawa, Kazuhiro Tamura, Toshiyuki Takeshita
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 89-95 (2017)
Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway
Autor:
Kazuhiro Sugahara, Sayomi Higa-Nakamine, Hideyuki Yamamoto, Seikichi Toku, Nobuhiro Noguchi, Ichiro Kukita, Noriko Maeda, Yutaka Kondo
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 3, Pp 287-293 (2014)
Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar. However, signif
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 4, Pp 347-354 (2014)
The ability to resist stress is an important defensive function of a living body. Thus, elucidation of the mechanisms by which the brain resists stress could help to pave the way for new therapeutic strategies for stress-related psychiatric disorders
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 4, Pp 211-217 (2016)
Sphingosine 1-phosphate (S1P) plays important roles in cardiovascular pathophysiology. S1P1 and/or S1P3, rather than S1P2 receptors, seem to be predominantly expressed in vascular endothelial cells, while S1P2 and/or S1P3, rather than S1P1 receptors,
Autor:
Hisayuki Uneyama, Ken Iwatsuki
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 123-128 (2012)
Recent advances in molecular biology have led to the investigation of the molecular mechanism by which chemicals such as odors and tastants are perceived by specific chemosensory organs. For example, G protein–coupled receptors expressed within the
Autor:
Koichiro Kuwahara, Kazuwa Nakao
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 337-342 (2011)
Genetic remodeling contributes to the progression of heart failure by affecting myocardial cellular function and survival. In our investigation of the transcriptional regulation of cardiac gene expression, we found several transcriptional pathways in
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 1, Pp 63-68 (2011)
Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human neutr
Autor:
Motohiro Nishida
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 1, Pp 1-5 (2011)
Heart failure is a major cause of death in developed countries, and the development of an epoch-making cure is desired from the viewpoint for improving the quality of life and reducing the medical cost of the patient. The importance of neurohumoral f
Autor:
Eiichi Hinoi, Yukio Yoneda
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 3, Pp 248-256 (2011)
The prevailing view is that l-glutamate (Glu) functions as an excitatory amino acid neurotransmitter through a number of molecular machineries required for the neurocrine signaling at synapses in the brain. These include Glu receptors for signal inpu
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 1, Pp 1-12 (2009)
Thiazolidinediones, peroxisome proliferators-activated receptor gamma (PPARγ) ligands, have been recognized as a potential therapeutic agents for the treatment of pathological neovascularization. In the present study, we examined the molecular mecha