Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yuma Yamada"'
Publikováno v:
Journal of Pharmaceutical Sciences. 111:432-439
Large amounts of ATP are produced in mitochondria especially in the brain and heart, where energy consumption is high compared with other organs. Thus, a decrease in ATP production in such organs could be a cause of many diseases such as neurodegener
Publikováno v:
Journal of pharmaceutical sciences. 111(2)
Large amounts of ATP are produced in mitochondria especially in the brain and heart, where energy consumption is high compared with other organs. Thus, a decrease in ATP production in such organs could be a cause of many diseases such as neurodegener
Autor:
Mitsue Hibino, Yusuke Sato, Yuma Yamada, Manabu Tokeshi, Masatoshi Maeki, Naoki Fujishita, Hideyoshi Harashima
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2668-2676
A number of drugs that are currently on the market, as well as new candidates for drugs, are poorly water soluble. Because of this, a need exists to develop drug formulations that will permit the expanded use of such drugs. The use of liposomes and l
Publikováno v:
Journal of Pharmaceutical Sciences. 107:647-653
Patients with type I diabetes, which is caused by the destruction of pancreatic islets, now require regular therapeutic injections of insulin. The use of transgene therapy represents an alternate and potent strategy for the treatment of type I diabet
Autor:
Yuma Yamada, Yusuke Sato, Yu Sakurai, Reina Munechika, Hideyoshi Harashima, Fumika Kubota, Satrialdi
Publikováno v:
Journal of pharmaceutical sciences. 109(8)
Mitochondrial delivery of an anticancer drug targeting cancer cells would eventually result in cell death. To achieve this, a drug delivery system targeting mitochondria is needed. We recently developed a MITO-Porter, a liposome that delivers its car
Autor:
Mitsue, Hibino, Yuma, Yamada, Naoki, Fujishita, Yusuke, Sato, Masatoshi, Maeki, Manabu, Tokeshi, Hideyoshi, Harashima
Publikováno v:
Journal of pharmaceutical sciences. 108(8)
A number of drugs that are currently on the market, as well as new candidates for drugs, are poorly water soluble. Because of this, a need exists to develop drug formulations that will permit the expanded use of such drugs. The use of liposomes and l
Publikováno v:
Journal of Pharmaceutical Sciences. 105(5):1705-1713
It has been reported that the use of mitochondrial RNA aptamers including RNase P (RP) results in the selective mitochondrial delivery of endogenous and exogenous RNAs. The issue of whether these aptamers would be useful ligands for the mitochondrial
Publikováno v:
Journal of Pharmaceutical Sciences. 105:734-740
Mitochondria in human cancer cells have been implicated in cancer cell proliferation, invasion, metastasis, and even drug-resistance mechanisms, making them a potential target organelle for the treatment of human malignancies. Gentamicin (GM), an ami
Publikováno v:
Journal of pharmaceutical sciences. 106(9)
Most anticancer drugs are intended to function in the nuclei of cancer cells. If an anticancer drug could be delivered to mitochondria, the source of cellular energy, this organelle would be destroyed, resulting in the arrest of the energy supply and
Autor:
Yuma Yamada, Jiro Abe, Yukari Yasuzaki, Hideyoshi Harashima, Mai Tabata, Sandra Milena Vergara Perez
Publikováno v:
Journal of pharmaceutical sciences. 104(9)
The transduction of antibodies into living cells would represent a major contribution to both basic and applied biomedical fields, as currently available methods suffer from limitations such as low-uptake efficiency and endosomal entrapment. In this