Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Blood drug"'
Autor:
Jeannie M. Padowski, Gary M. Pollack
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3226-3233
The central nervous system (CNS), efficiently isolated from the systemic circulation by the blood-brain barrier (BBB), represents a challenging therapeutic target. For CNS-targeted agents, augmenting brain exposure by increasing blood drug concentrat
Publikováno v:
Journal of Pharmaceutical Sciences. 96:595-602
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs in the world, primarily for symptoms associated with osteoarthritis and other chronic musculoskeletal conditions. However, adverse effects caused by oral administr
Autor:
Katsumi Iga
Publikováno v:
Journal of pharmaceutical sciences. 104(4)
Using a three-compartment physiologically based pharmacokinetic (PBPK) model and a tube model for hepatic extraction kinetics, equations for calculating blood drug levels (Cb s) and hepatic blood drug levels (Chb s, proportional to actual hepatic dru
Publikováno v:
Journal of pharmaceutical sciences. 80(9)
The accuracy of different blood sampling methods used to characterize rapidly changing blood drug concentrations was examined both in vitro and in vivo. It was shown in vitro that blood sampling methods based on the fraction collection principle fail
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1411-1413
The blood levels of propranolol in rats and dogs were compared after the administration of nasal, intravenous, and oral solutions. The results indicate that the blood drug levels after nasal and intravenous administration were identical, but the oral
Autor:
Sampat M. Singhvi
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1499-1501
Occasionally, it is desirable to attain steady-state-state blood drug levels rapidly in pharmacokinetic studies as well as in the treatment of certain diseases. In these cases, it is useful to administer an intravenous priming dose in combination wit
Publikováno v:
Journal of pharmaceutical sciences. 67(2)
Various cephalosporins with different degrees of protein binding were administered to human volunteers. Blood samples were collected as a function of time and were assayed for drug content by a microbiological assay. A pharmacokinetic analysis of the
Autor:
L.G. Miller, Julian H. Fincher
Publikováno v:
Journal of pharmaceutical sciences. 60(11)
Phenobarbital suspensions containing drug particles of different size ranges were separately administered, intramuscularly, to beagle dogs. The particle size of the dose affected the blood drug level curves. A comparison of the areas under the curves
Autor:
K.K. Midha
Publikováno v:
Journal of Pharmaceutical Sciences. 68:805