Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Constantinos K. Zacharis"'
Autor:
Stefanos, Ntontis, Eleni, Tsanaktsidou, Paraskevas D, Tzanavaras, Kyriakos, Kachrimanis, Catherine K, Markopoulou, Constantinos K, Zacharis
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 224:115186
Herein, the development of a HILIC method for the determination of imidazole (Imp E) in sildenafil citrate API and its final formulations is reported. The main goal of this study was to develop a robust, application-specific HPLC method according to
Autor:
Paraskevas D. Tzanavaras, Aikaterini-Theodora Chatzitaki, Christina Karavasili, Yiannis Sarigiannis, Dimitrios G. Fatouros, Constantinos K. Zacharis
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 214
In this article, a UHPLC-PDA method has been developed using the quality-by-design (QbD) principles for the determination of the therapeutic peptide - octreotide - in its in vitro released samples. Due to the complexity of the peptide-based hydrogel
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 219:114921
Although almost 60 years have passed since their first application, bisphosphonates are still in use as medicine against osteoporosis. Due to their chemical structures and properties, these compounds have attracted the attention of many scientists. F
Autor:
Victoria F. Samanidou, Konstantina Mazaraki, Constantinos K. Zacharis, Konstantinos Fytianos, Abuzar Kabir, Kenneth G. Furton
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 199
A fast fabric phase sorptive extraction method is presented herein for the rapid isolation of selected beta-blocker drugs from human serum and urine. Among many high efficiency sol-gel sorbent coated FPSE membranes, sol-gel CW20 M coated FPSE membran
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 150:152-161
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepi
Autor:
Marlen Christofi, Paraskevas D. Tzanavaras, Constantinos K. Zacharis, Catherine K. Markopoulou
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 187:113354
The present approach poses an interesting way to quantify residues of the genotoxic impurity hydrazine in allopurinol and its pharmaceutical formulations using ultra high performance liquid chromatography coupled to fluorescence detection. Hydrazine
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 177:112887
In the present study we report a fully automated method for the determination of low levels of the genotoxic impurity hydrazine in allopurinol active pharmaceutical ingredient (API) and formulations based on the concept of zone-fluidics. Hydrazine re
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 53:790-794
In the present study we report new data on the reaction of three representative thiols – captopril (CAP), cysteine (CYS) and N-acetylcysteine (NAC) – with two commercially available propiolate esters – methyl-propiolate (MP) and butyl-propiolat
Autor:
Maria Notou, Anastasia Zotou, Constantinos K. Zacharis, Demetrius G. Themelis, Paraskevas D. Tzanavaras
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 49:201-206
A micellar electrokinetic chromatography (MEKC) method has been developed and validated for the determination of nimesulide related compounds in pharmaceutical formulations. Electrophoretic separation of six European Pharmacopoeia (EP) impurities (A-
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 48:1254-1260
The first automated method for the determination of mexiletine hydrochloride - an antiarrhythmic agent - is reported. The method is based on the reaction of the analyte with o-phthalaldehyde (OPA) in the presence of sulfite in basic medium using a se