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Autor:
Janusz Menkiszak, Jerzy Jakubowicz, Zbigniew Kojs, Maria Świniarska, Jacek Gronwald, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Dorota Zielińska, Ryszard Bedner, Aleksander Celewicz, Paulina Tarnowska, Małgorzata Wężowska
Publikováno v:
Journal of Ovarian Research
Background There are no effective methods of diagnosis of early-stage ovarian cancer. Conservative care over patients at high risk of ovarian and breast cancers is ineffective. Prophylactic surgery is considered the best prophylaxis among BRCA1/BRCA2
Autor:
Rishi Deka, David D. Stenehjem, Vanessa Stevens, Marisa B. Schauerhamer, Sudhir Unni, Ancilla W. Fernandes, Diana I. Brixner, Jerzy E. Tyczynski
Publikováno v:
Journal of Ovarian Research
Background Breast cancer associated (BRCA) genes are critical for DNA repair. Mutations in BRCA1 and BRCA2 (BRCAm) result in loss of these repair mechanisms and potential carcinogenesis. Germline BRCAm are common in ovarian carcinomas, particularly i