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Autor:
Sandrine Combret, Aurélie Grandvuillemin, Charlène Boulay, Pauline Lory, Didier Mayeur, Antonin Schmitt, Nils Martin, Jeffrey Lombardi
Publikováno v:
Journal of Oncology Pharmacy Practice. 27:2041-2044
Introduction Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate which combine trastuzumab (T), a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), and a cytotoxic molecule derived from maytansine (DM1). Case
Publikováno v:
Journal of Oncology Pharmacy Practice. 27:119-127
Introduction Methotrexate (MTX) is a cytotoxic antimetabolite. Intravenous (IV) hydration and urine alkalinization with sodium bicarbonate (NaHCO3) can mitigate nephrotoxicity associated with high-dose MTX (HDMTX, doses ≥500 mg/m2). A shortage of I
Autor:
Michael Dineen, Elizabeth A. Guancial, Elizabeth Hansen, Lynn Sievert, Deepak M. Sahasrabudhe
Publikováno v:
Journal of Oncology Pharmacy Practice. 24:314-318
Abiraterone, a CYP17 inhibitor, blocks androgen biosynthesis in multiple tissue types. In combination with prednisone, it is approved as a first-line treatment for metastatic castration-resistant prostate cancer. We present a case of rhabdomyolysis a