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Publikováno v:
Journal of Oncology Pharmacy Practice. 28:703-709
Introduction Capecitabine is an orally administered prodrug that converts preferentially to 5-fluorouracil within tumors, resulting in enhanced concentrations of 5-fluorouracil in tumor tissue. The use of capecitabine has shown efficacy in the metast
Autor:
Diane Pannier, Ilyes Sakji, Geoffrey Strobbe, Frédéric Feutry, Alexandre Villain, Guillaume Marliot
Publikováno v:
Journal of Oncology Pharmacy Practice. 26:1743-1749
IntroductionDrug interactions involving everolimus are fairly well known because of its common use, primarily as an immunosuppressant. Several recommendations regarding therapeutic drug monitoring are also available for the use of everolimus-based im
Publikováno v:
Journal of Oncology Pharmacy Practice. 26:543-548
Background In cancer patients treated with vancomycin, therapeutic drug monitoring is currently performed by the Bayesian method that involves estimating individual pharmacokinetics from population pharmacokinetic parameters and trough concentrations
Publikováno v:
Journal of Oncology Pharmacy Practice. 23:75-79
Purpose Patients undergoing hematopoietic cell transplantation are treated with multiple medications, potentially complicated by drug–drug interactions. Drug interactions with sirolimus, voriconazole, and rifampin are particularly difficult because
Autor:
Ranjit Joseph, Constantin A Dasanu
Publikováno v:
Journal of Oncology Pharmacy Practice. 20:393-396
This report presents a unique case of oxaliplatin-induced neurotoxicity featuring acute, recurrent, self-limiting dysarthria following multiple subsequent infusions of oxaliplatin. A 65-year-old man started chemotherapy for metastatic pancreatic aden
Autor:
Larysa Skivka, N Bezdeneznikh, YuI Kudryavets, N Semesiuk, O. O. Lykhova, O O Trompak, YaM Susak
Publikováno v:
Journal of Oncology Pharmacy Practice. 17:339-349
Background. NSC-631570 (Ukrain) is a semisynthetic derivative of the Chelidonium majus alcaloids and the alkylans thiotepa. It exerts a selective cytotoxic effect on tumor cells in vitro and in vivo and shows the ability to modulate immunocyte functi
Autor:
J-L Misset, C Le Maignan, N Lejri, Guilhem Bousquet, Anne-Lise Pouliquen, François Lokiec, C Bauer
Publikováno v:
Journal of Oncology Pharmacy Practice. 17:265-269
Although testicular cancers are highly curable malignancies, conventional cisplatin based therapy often causes important toxicities, not often easily manageable. Nephrotoxicity occurs in almost all patients, and is potentialized in patients suffering
Autor:
Constantin A Dasanu
Publikováno v:
Journal of Oncology Pharmacy Practice. 17:282-284
Although rare, cardiac rhythm abnormalities have been documented with bortezomib use in clinical trials. These side effects must be recognized promptly by physicians of various specialties as well as pharmacists. Special attention is required in pati