Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Asla Pitkänen"'
Autor:
Tomi Paananen, Asla Pitkänen, Karthik Chary, Niina Lapinlampi, Alejandra Sierra, Eppu Manninen, Jussi Tohka, Pedro Andrade, Olli Gröhn
Publikováno v:
Journal of Neurotrauma. 37:2580-2594
Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxat...
Autor:
Eppu, Manninen, Karthik, Chary, Niina, Lapinlampi, Pedro, Andrade, Tomi, Paananen, Alejandra, Sierra, Jussi, Tohka, Olli, Gröhn, Asla, Pitkänen
Publikováno v:
Journal of neurotrauma. 37(23)
Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T
Autor:
Asla Pitkänen, Leonardo Lara-Valderrábano, Jenni Karttunen, Xavier Ekolle Ndode-Ekane, Mehwish Anwer, Noora Puhakka
Publikováno v:
Journal of neurotrauma. 37(7)
Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophy
Publikováno v:
Journal of Neurotrauma. 34:1482-1487
Sleep disturbances commonly occur after traumatic brain injury (TBI) and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence post-TBI depends on the sleep-wake cycle, and that the electrographic character
Autor:
Carmen Barba, Gabriella Colicchio, Alejandra Sierra Lopez, Joanna K. Huttunen, Olli Gröhn, Asla Pitkänen, Xavier Ekolle Ndode-Ekane, Juha-Pekka Niskanen, Artem Shatillo, Antti M. Airaksinen
Publikováno v:
Journal of neurotrauma. 35(22)
Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level-dependent (BOLD) response in functional magnetic res
Autor:
Alejandra Sierra, Joanna K. Huttunen, Pasi A. Karjalainen, Jari Nissinen, Olli Gröhn, Antti M. Airaksinen, Asla Pitkänen, Juha-Pekka Niskanen
Publikováno v:
Journal of Neurotrauma. 30:546-556
The present study was designed to test a hypothesis that functional magnetic resonance imaging (fMRI) can be used to monitor functional impairment and recovery after moderate experimental traumatic brain injury (TBI). Moderate TBI was induced by late
Publikováno v:
Journal of neurotrauma. 34(2)
We aimed to generate two-dimensional (2D) unfolded cortical maps from magnetic resonance (MR) images to delineate the location of traumatic brain injury (TBI)-induced cortical damage in functionally diverse cytoarchitectonic areas of the cerebral cor
Autor:
Tamuna Bolkvadze, Asla Pitkänen
Publikováno v:
Journal of neurotrauma. 29(5)
The present study investigated the development of hyperexcitability and epilepsy in mice with traumatic brain injury (TBI) induced by controlled cortical impact (CCI) or lateral fluid-percussion injury (FPI), which are the two most commonly used expe
Association of chronic vascular changes with functional outcome after traumatic brain injury in rats
Autor:
Olli Gröhn, Xavier Ekolle Ndode-Ekane, Pasi I Tuunanen, Nick Hayward, Riikka Immonen, Asla Pitkänen
Publikováno v:
Journal of neurotrauma. 27(12)
We tested the hypothesis that vascular remodeling in the cortex, hippocampus, and thalamus is associated with long-term functional recovery after traumatic brain injury (TBI). We induced TBI with lateral fluid-percussion (LFP) injury in adult rats. A
Autor:
Tracy K. McIntosh, Asla Pitkänen
Publikováno v:
Journal of neurotrauma. 23(2)
Epilepsy is a major unfavorable long-term consequence of traumatic brain injury (TBI). Moreover, TBI is one of the most important predisposing factors for the development of epilepsy, particularly in young adults. Understanding the molecular and cell