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Autor:
Qiang Wang, Kyle McMillan, Aaron P. Fox, Zheng Xie, Bruce E. Herring, Carolyn M. Pike, Anne L. Cahill
Publikováno v:
Journal of Neurophysiology. 109:758-767
General anesthetics produce anesthesia by depressing central nervous system activity. Activation of inhibitory GABAA receptors plays a central role in the action of many clinically relevant general anesthetics. Even so, there is growing evidence that
Publikováno v:
Journal of Neurophysiology. 109:803-812
Subacute and chronic changes in tonic GABAergic inhibition occur in human and experimental epilepsy. Less is known about how tonic inhibition is modulated over shorter time frames (seconds). We measured endogenous tonic GABA currents from cultured ra
Publikováno v:
Journal of Neurophysiology. 107:1022-1031
Our laboratory previously reported that gastric activity is controlled by a robust GABAA receptor-mediated inhibition in the medial nucleus of the tractus solitarius (mNTS) ( Herman et al. 2009 ), and that μ-opioid receptor activation inhibits gastr
Autor:
G. Aleph Prieto, José Bargas, Marcela Palomero-Rivero, René Drucker-Colín, Azucena Perez-Burgos, Elvira Galarraga
Publikováno v:
Journal of Neurophysiology. 105:2260-2274
The loss of dopaminergic neurons in the substantia nigra compacta followed by striatal dopamine depletion is a hallmark of Parkinson's disease. After dopamine depletion, dopaminergic D2receptor (D2R)-class supersensitivity develops in striatal neuron
Publikováno v:
Journal of Neurophysiology. 103:1905-1914
The transmembrane distribution of chloride anions (Cl−) determines the direction of the Cl− flux through GABAA receptors; this establishes whether GABAA receptor-mediated responses are hyperpolarizing or depolarizing in neurons. Thus an activity-
Publikováno v:
Journal of Neurophysiology. 103:1007-1019
Protein kinase A (PKA) has been reported to regulate synaptic alphabetagamma gamma-aminobutyric acid type A (GABA(A)) receptor currents, but whether PKA regulates GABA(A) receptor peri- and extrasynaptic tonic currents is unknown. GABA(A) receptors c
Publikováno v:
Journal of Neurophysiology. 102:1265-1273
Despite their importance, the mechanism of action of general anesthetics is still poorly understood. Facilitation of inhibitory GABAA receptors plays an important role in anesthesia, but other targets have also been linked to anesthetic actions. Anes
Publikováno v:
Journal of Neurophysiology. 100:1420-1432
The opioid receptor-like 1 (NOP or ORL1) receptor is a G-protein-coupled receptor the endogenous ligand of which is the heptadecapeptide, nociceptin (Noc). NOP receptors are known to modulate pain processing at spinal, supraspinal, and peripheral lev
Publikováno v:
Journal of Neurophysiology. 100:1147-1151
The effect of N-arachidonoyl l-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and r
Publikováno v:
Journal of Neurophysiology. 99:2985-2997
Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the ne