Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mahmoud A. Pouladi"'
Autor:
Michael R. Hayden, Yihui Huang, Liang Juin Tan, Nicholas S. Caron, Xuan Vinh To, Rachel Yanping Lin, Marta Garcia Miralles, Spyros Papapetropoulos, Kai-Hsiang Chuang, Xin Hong, Liat Hayardeny, Sonia Franciosi, Mahmoud A. Pouladi
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A92.3-A93
Background Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington’s disease (HD). Aim and method In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immu
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A13.3-A14
Background Misfolding and altered conformation of huntingtin (HTT) as a result of an expanded polyglutamine tract in its N-terminus is thought to be the primary cause of Huntington’s disease (HD). The misfolding of HTT in its mutant form leads to g
Autor:
Marta Garcia Miralles, Madeline Lim, Michal Geva, Liang Juin Tan, Mahmoud A. Pouladi, Michael R. Hayden
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A92.1-A92
Pridopidine is currently in clinical development for Huntington’s disease (HD) and investigations to increase the understanding of its therapeutic benefit and mode of action are undergoing. In this study, we aim to investigate the efficacy and mech
Autor:
Mélissa Laroche, C Kreidy, Marta Garcia-Miralles, Mélissa Lessard-Beaudoin, Huu Phuc Nguyen, Libo Yu-Tager, Mahmoud A. Pouladi, Michael R. Hayden, Rona K. Graham
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A24.1-A24
Background Olfactory dysfunction and altered neurogenesis are observed in several neurodegenerative disorders including Huntington’s disease (HD). These deficits are an early symptom and correlate with decline in cognitive performance, depression a
Autor:
Yihui Huang, George J. Augustine, Donovan Low, Carola I. Radulescu, Marie Loh, Xiaohong Xu, Yilin Tay, Florent Ginhoux, Bernice Sim, Su-In Yoon, Kagistia Hana Utami, Mahmoud A. Pouladi, Jolene Ooi
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A27.1-A27
Human induced pluripotent stem cells (hiPSCs) derived from Huntington’s disease (HD) patients provide a physiologically relevant cellular platform for disease modelling and drug screening studies. However, hiPSCs reprogramed from different individu
Autor:
Rona K. Graham, Mélissa Laroche, Marie-Josée Demers, C Kreidy, Hayden, Mahmoud A. Pouladi, Mélissa Lessard-Beaudoin, Sonia Franciosi, Marta Garcia-Miralles
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A23-A24
Olfactory dysfunction and altered neurogenesis are observed in several neurodegenerative disorders including Huntington disease (HD). These deficits are an early symptom and correlate with decline in global cognitive performance, depression and degen
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A22-A22
Monoamine oxidases (MAO) are an important component of the homeostatic machinery that maintains the levels of monoamine neurotransmitters, including dopamine, in balance. Given the imbalance in dopamine levels observed in HD, the aim of this study wa
Autor:
W-N Zhang, Patrick Poucheret, E Brilluad, Sonia Franciosi, J-C Maurel, Yuanyun Xie, Mahmoud A. Pouladi, Elsa Compte, Michael R. Hayden, Christian Neri, M Zapala
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 81:A15.1-A15
Background Huntington9s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the HD gene, remains without a cure. Lithium, a drug widely used for the treatment of bipolar disorder, has been shown to exert neuroprotective eff
Autor:
Michael R. Hayden, Rona K. Graham, Nagat Bissada, Sonia Franciosi, Yuanyun Xie, Y Deng, Kuljeet Vaid, Mahmoud A. Pouladi
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 81:A2.1-A2
Background The amelioration of behavioural and neuropathological deficits in mice expressing caspase 6 resistant (C6R) mutant huntingtin (mhtt), despite the presence of an expanded polyglutamine track, highlights proteolysis of htt at the 586aa caspa
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 81:A14.2-A14
Background Huntington9s Disease (HD) is an inherited neurological disorder characterised by loss of motor coordination, cognitive dysfunction and psychiatric disturbances that remains without a cure. Arimoclomol, a compound reported to enhance cellul