Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Elisabeth Singer"'
Autor:
Huu P. Nguyen, Jonasz J. Weber, Carolin Walter, Elisabeth Singer, LE Clemens, Ulrike A. Mau-Holzmann, Ann-Christin Krahl, Nadine Rischert
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A27.3-A28
Background The ST Hdh cell lines are immortalised striatal precursor cells from wild type and Hdh Q111 knock-in mice and are commonly used to study the molecular aspects of HD. Morphological differences between the wild type and mutant cell lines exi
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A93.2-A93
Background The pathogenesis of HD is not entirely understood, but it is clear that the expression of the disease-causing mutant huntingtin protein leads to the disruption of a variety of cellular functions, which ultimately results in cell death. A h
Autor:
Olaf Riess, LE Clemens, Lukas Klumpp, Carolin Walter, M Gierke, Elisabeth Singer, Stephan M. Huber, Jonasz J. Weber, Huu P. Nguyen
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A10-A10
Background Calpains (CAPNs), a class of intracellular calcium-dependent cysteine proteases, belong to the group of proteolytic enzymes which have been associated with the cleavage of mutant huntingtin (Htt), the source for toxic fragments of the dise