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Autor:
Ray Wynford-Thomas, Neil Robertson
Publikováno v:
Journal of Neurology
Neuromyelitis optica spectrum disorder (NMO-SD) has a worldwide prevalence of 0.5–10 persons per 100,000 population. It is characterised by inflammatory events centred on the optic nerve and spinal cord, often with poor recovery and subsequent resi
Autor:
Ralf Gold, Aiden Haghikia, Maren Peschke, Gisa Ellrichmann, Kerstin Hellwig, De-Hyung Lee, Jan Bolz, Alexander Duscha, Ralf A. Linker
Publikováno v:
Journal of Neurology
Background With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-la
Autor:
Klaus Schmierer, Francesca Ammoscato, Helen Lock, David Baker, Zhifeng Mao, Bryan Ceronie, Hilary Longhurst, Benjamin Meir Jacobs, Nicolas Dubuisson, Gavin Giovannoni
Publikováno v:
Journal of Neurology
Background The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. Objective To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-mod
Autor:
Mariko Hokari, Masatoyo Nishizawa, Musashi Arakawa, Naomi Mezaki, Jun Tokunaga, Naoko Sakai, Kota Utsumi, Akari Takeshima, Miura Takeshi, Akio Yokoseki, Tetsutaro Ozawa, Atsushi Ishikawa, Ryoko Takeuchi, Takashi Kondo
Publikováno v:
Journal of Neurology
Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion i