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Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Changes in dopaminergic neural function can be induced by an acute inflammatory state that, by altering the integrity of the neurovasculature, induces neuronal stress, cell death and causes functional deficits. Effectively blocking these e
Autor:
Jaya S P Jayaseelan, Natalia D Djukic, Richard J. Woodman, Hakan Muyderman, Wai Ping Yew, Neil R. Sims
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological function and in treatment-induced improvements in function. Microglia and astrocytes i
Autor:
Hao-Nan Li, Qing-Qing Yang, Xue Tian, Fan Feng, Yuan-Wu Zou, Wen-Tao Wang, Shu-Ting Zhang, Xiao-Yan Zeng, Jia-Xue Wang, Jun-Yang Wang, Yu-Tong Xia
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-20 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokines. Here, we further explored
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is
Autor:
Iain L. Campbell, Rachel Louise Terry, Thomas M. Ashhurst, Claire L. Wishart, Nicholas J. C. King, Markus J. Hofer, Alanna Gabrielle Spiteri
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundDifferentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenotype. This
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Repetitive mild traumatic brain injury (mTBI) can result in chronic visual dysfunction. G-protein receptor 110 (GPR110, ADGRF1) is the target receptor of N-docosahexaenoylethanolamine (synaptamide) mediating the anti-neuroinflammatory func
Autor:
Li Ming Chen, Yan Huang, Di Wang, Huan Gan Wu, Chun Hui Bao, Lu Yi Wu, Yu Wu, Shi Hua Liang, Hui Rong Liu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depr
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide; more than 10 million people are hospitalized for TBI every year around the globe. While the primary injury remains unavoidable and not accessible to tre
Autor:
Bumseok Kim, Seong Kug Eo, Ajit Mahadev Patil, Seong Ok Park, Erdenebelig Uyangaa, Jin Young Choi, Koanhoi Kim
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-26 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background The crucial role of type I interferon (IFN-I, IFN-α/β) is well known to control central nervous system (CNS) neuroinflammation caused by neurotrophic flaviviruses such as Japanese encephalitis virus (JEV) and West Nile virus. However, an
Autor:
Xiaoan Zhang, Wei-Na Jin, Yan Feng, Fu-Dong Shi, Hui Zhao, Yan Li, Ying Zhang, Xin Zhao, Bo-Hao Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundBrain ischemia compromises natural killer (NK) cell-mediated immune defenses by acting on neurogenic and intracellular pathways. Less is known about the posttranscriptional mechanisms that regulate NK cell activation and cytotoxicity after