Zobrazeno 1 - 10
of 31
pro vyhledávání: ''
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Background Treatment-resistant depression (TRD) and pain frequently coexist clinically. Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD pa
Autor:
Emanuela Esposito, Timothy M. Doyle, Daniela Salvemini, Susan A. Farr, Michela Campolo, Michael L. Niehoff, Salvatore Cuzzocrea
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Background Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence
Autor:
Vicky Staikopoulos, Kathryn Braden, Zhoumou Chen, Kali Janes, Timothy M. Doyle, William L. Neumann, Daniela Salvemini, Sarah Spiegel, Mark R. Hutchinson
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be eith
Autor:
Yunfeng Li, Yiming Lu, Yuan Dong, Yajin Liao, Zengqiang Yuan, Lin Hou, Shuoshuo Li, Jinbo Cheng, Xiaoheng Li, Zhixin Peng
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- and stress-related disorders such as posttraumatic stress disorder (PTSD) and anxiety disorder. Despite the abundant discoveries of neuro
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Background In early autoimmune neuroinflammation, interferon (IFN)γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Although dysregulation of the iP h
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Background The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson’s disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that mi
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-11 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-11 (2020)
Background Dry skin itch is one of the most common skin diseases and elderly people are believed to be particularly prone to it. The inflammasome has been suggested to play an important role in chronic inflammatory disorders including inflammatory sk
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative disorders such as Alzheimer’s disease (AD). Although studies indicate that chronic pain correlates with cognitive decline, it is unclear whether chronic p
Autor:
Tetsuya Tamaru, Yasuharu Nakashima, Masatake Tanaka, Shingo Yoshizaki, Masamitsu Hara, Takeyuki Saito, Seiji Okada, Daijiro Konno, Ken Kijima
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Background Spinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is increasing interest in tranexamic acid (TXA), an anti-fibrinolytic drug, which can reduce the bleeding volume