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Autor:
David Palmer, Graham W. Kay
Publikováno v:
Journal of Neuroinflammation
Background The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated 1:12,500 live births worldwide. They are caused by mutations in at least 11 different genes. Currently
Publikováno v:
Journal of Neuroinflammation
Background The investigation of the environmental contribution for developmental neurotoxicity is very critical. Many environmental chemical exposures are now thought to contribute to the development of neurological disorders, especially in children.
Autor:
Randall O Dull, Sergey Kalinin, Guy L. Weinberg, David E. Schwartz, Anthony Sharp, Paul E. Polak, Richard Ripper, Douglas L. Feinstein, Israel Rubinstein
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 9, Iss 1, p 272 (2012)
Journal of Neuroinflammation, Vol 9, Iss 1, p 272 (2012)
Background Inhalational anesthetics have been shown to influence T cell functions both in vitro and in vivo, in many cases inducing T cell death, suggesting that exposure to these drugs could modify the course of an autoimmune disease. We tested the
Autor:
Emily N. Mangano, Shawn Hayley, Jessica Bobyn, Melanie Clarke, Anusha Gandhi, Kerry Moloney, Eric Nelson
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 9, Iss 1, p 86 (2012)
Journal of Neuroinflammation, Vol 9, Iss 1, p 86 (2012)
Abstract Background Parkinson’s disease (PD) has been linked with exposure to a variety of environmental and immunological insults (for example, infectious pathogens) in which inflammatory and oxidative processes seem to be involved. In particular,
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 9, Iss 1, p 63 (2012)
Journal of Neuroinflammation, Vol 9, Iss 1, p 63 (2012)
Background Inflammation is known to play a pivotal role in mediating neuronal damage and axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory mediators, nitric oxide and hydrogen peroxide are potent neurotoxic ag
Autor:
Andrea Mayado, María Dolores Gutiérrez-López, María Isabel Colado, Esther O'Shea, Elisa Torres
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 8, Iss 1, p 165 (2011)
Journal of Neuroinflammation, Vol 8, Iss 1, p 165 (2011)
Background Preconditioning is a phenomenon by which tolerance develops to injury by previous exposure to a stressor of mild severity. Previous studies have shown that single or repeated low dose MDMA can attenuate 5-HT transporter loss produced by a
Autor:
Tobias Cronberg, David Ley, Corrado M. Cilio, Stefan R. Hansson, Tadeusz Wieloch, Tina Markus
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 7, Iss 1, p 94 (2010)
Journal of Neuroinflammation; 7 (2010)
Journal of Neuroinflammation, Vol 7, Iss 1, p 94 (2010)
Journal of Neuroinflammation; 7 (2010)
Background Inflammation acting in synergy with brain ischemia aggravates perinatal ischemic brain damage. The sensitizing effect of pro-inflammatory exposure prior to hypoxia is dependent on signaling by TNF-α through TNF receptor (TNFR) 1. Adrenoce
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 6, Iss 1, p 37 (2009)
Journal of Neuroinflammation, Vol 6, Iss 1, p 37 (2009)
Background Glucocorticoids have been shown to be effective in the treatment of autoimmune diseases of the CNS such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the mechanisms and the site of gl
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 5, Iss 1, p 8 (2008)
Journal of Neuroinflammation, Vol 5, Iss 1, p 8 (2008)
Background The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can t
Autor:
Juan Herrero, M. Mar Curros-Criado
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 4, Iss 1, p 15 (2007)
Journal of Neuroinflammation, Vol 4, Iss 1, p 15 (2007)
Background Gabapentin is a structural analogue of gamma-aminobutyric acid with strong anticonvulsant and analgesic activities. Important discrepancies are observed on the effectiveness and potency of gabapentin in acute nociception and sensitization