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Autor:
Emanuela Esposito, Timothy M. Doyle, Daniela Salvemini, Susan A. Farr, Michela Campolo, Michael L. Niehoff, Salvatore Cuzzocrea
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Background Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury. Evidence
Autor:
Vicky Staikopoulos, Kathryn Braden, Zhoumou Chen, Kali Janes, Timothy M. Doyle, William L. Neumann, Daniela Salvemini, Sarah Spiegel, Mark R. Hutchinson
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Background The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson’s disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that mi
Autor:
Tetsuya Tamaru, Yasuharu Nakashima, Masatake Tanaka, Shingo Yoshizaki, Masamitsu Hara, Takeyuki Saito, Seiji Okada, Daijiro Konno, Ken Kijima
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Background Spinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is increasing interest in tranexamic acid (TXA), an anti-fibrinolytic drug, which can reduce the bleeding volume
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Background Neuroinflammation is an essential player in many neurological diseases including traumatic brain injury (TBI). Recent studies have identified that inflammasome complexes are responsible for inflammatory responses in many pathological condi
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Background Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEGF) agents
Autor:
Chun Wang, Lin Wang, Yucong Peng, Jianru Li, Jingsen Chen, Cheng Wu, Sheng Nie, Linfeng Fan, Zhi-jiang Wang, Gao Chen, C. Charles Gu, Jingyin Chen, Hangzhe Xu, Feng Yan
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Background The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many dis
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-10 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-10 (2017)
Atypical antipsychotic agents, such as clozapine, are used for treating psychosis and depression and have recently been found to modulate neuroinflammation. We have shown previously that treatment of mice with the atypical antipsychotic agents, cloza
Publikováno v:
Journal of Neuroinflammation
Background Acute glaucoma is a significantly sight-threatening cause of irreversible blindness in the world characterized by a sudden and substantial intraocular pressure (IOP) increase and subsequent retinal ganglion cell (RGC) death. This study aim
Autor:
Olivier Pétrault, Catherine Lefebvre, Sophie Gautier, Thavarak Ouk, Maud Laprais, Régis Bordet, Annabelle Dupont, Madjid Tagzirt, Didier Leys
Publikováno v:
Journal of Neuroinflammation
Background Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen a