Zobrazeno 1 - 10
of 1 046
pro vyhledávání: '"Blotting, Western"'
Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat
Autor:
Aaron M. Swomley, Jian Cai, Miranda E. Orr, Jessime Kirk, Judy C. Triplett, Jon B. Klein, Rochelle Buffenstein, Katilyn Lewis, D. Allan Butterfield, Karl A. Rodriguez
Publikováno v:
Journal of Neurochemistry. 134:538-550
Naked mole-rats (NMRs) are the oldest-living rodent species. Living underground in a thermally stable ecological niche, NMRs have evolved certain exceptional traits, resulting in sustained health spans, negligible cognitive decline, and a pronounced
Publikováno v:
Journal of Neurochemistry. 134:551-565
Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer's disease and multiple sclerosis. Tetramethylpyrazine (TMP), a major bioactive component purified from Ligusticum wallichii Franchat, exhibited pot
Publikováno v:
Journal of Neurochemistry. 134:288-301
The existence of an intrinsic programme controlling neuritogenesis and activated during early neuronal differentiation and regeneration stages is well established. However, the identity and role of each molecular player and event, as well as how such
Publikováno v:
Journal of Neurochemistry. 134:578-589
General transcription factor II-I (Gtf2i) is a transcription factor and one of the genes implicated in Willams–Beuren syndrome, an autism spectrum disorder. In this study, we investigated splice variants of the Gtf2i gene in both the 5'untranslated
Autor:
Diego Piedrahita, Alejandro López-Tobón, Christian Gonzalez-Billault, Rafael Andrés Posada-Duque, Gloria Patricia Cardona-Gómez
Publikováno v:
Journal of Neurochemistry. 134:354-370
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we demonstrated that RNAi knock
Autor:
Eun-Jung Kim, Harald Höger, Sunetra Sase, Marion Gröger, Ana Cicvaric, Johannes Berger, Fernando J. Sialana, Gert Lubec, Francisco J. Monje, Gangsoo Jung
Publikováno v:
Journal of Neurochemistry. 134:327-339
Drebrin an actin-bundling key regulator of dendritic spine genesis and morphology, has been recently proposed as a regulator of hippocampal glutamatergic activity which is critical for memory formation and maintenance. Here, we examined the effects o
Publikováno v:
Journal of Neurochemistry. 134:1015-1025
The brain-derived neurotrophic factor (BDNF) gene contains a number of 5′ exons alternatively spliced with a common 3′ exon. BDNF protein is synthesized from alternative transcripts as a prepro-precursor encoded by the common 3′ exon IX, which
Autor:
Chunyan Zhang, Wenbin Wan, Lan Cao, Bill Kalionis, Xiantao Tai, Shijin Xia, Lumei Liu, Yaming Li
Publikováno v:
Journal of Neurochemistry. 134:382-393
Accumulating evidence indicates that abnormal deposition of amyloid-β (Aβ) peptide in the brain is responsible for endothelial cell damage and consequently leads to blood–brain barrier (BBB) leakage. However, the mechanisms underlying BBB disrupt
Autor:
Hans Werner Müller, Frank Bradke, Malleswari Challagundla, Thomas Ostendorf, Uwe Michel, Vinicius Toledo Ribas, Mathias Bähr, Sebastian Kügler, Paul Lingor, Jan C. Koch
Publikováno v:
Journal of neurochemistry 134(2), 261-275 (2015). doi:10.1111/jnc.13102
A lesion to the rat rubrospinal tract is a model for traumatic spinal cord lesions and results in atrophy of the red nucleus neurons, axonal dieback, and locomotor deficits. In this study, we used adeno-associated virus (AAV)-mediated over-expression
Autor:
Trine Meldgaard Lund, Inger Jansen-Olesen, Kenneth Beri Ploug, Anne Iversen, Anders A. Jensen
Publikováno v:
Lund, T M, Ploug, K B, Iversen, A, Jensen, A A & Jansen-Olesen, I 2015, ' The metabolic impact of β-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity ', Journal of Neurochemistry, vol. 132, no. 5, pp. 520-531 . https://doi.org/10.1111/jnc.12975
Glucose is the main energy substrate for neurons, and ketone bodies are known to be alternative substrates. However, the capacity of ketone bodies to support different neuronal functions is still unknown. Thus, a change in energy substrate from gluco