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Autor:
Robert K Leśniak, Steven Andrew Baker, Curt R. Fischer, Nay L. Saw, Kathleen S. Montine, Thomas J. Montine, Adam M. Wawro, Mehrdad Shamloo, Chandresh R. Gajera
Publikováno v:
Journal of Neurochemistry. 158:1074-1082
Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders. Recently, we described enantiomer-specific effects of 2-methylglutamate, which is not decarbo
Autor:
Caroline E. Bass, Megan Vik, Caitlin Szalkowski, Jinwoo Park, Ken T. Wakabayashi, Rohan V. Bhimani
Publikováno v:
J Neurochem
Methamphetamine (METH) is a potent psychostimulant that exerts many of its physiological and psychomotor effects by increasing extracellular dopamine (DA) concentrations in limbic brain regions. While several studies have focused on how potent, neuro
Autor:
Shaolei Luo, Bruce S. McEwen, Yangyang Hou, Peixiong Yuan, Yue Jia, Husseini K. Manji, Lei Feng, Yaping Zhang, Richard G. Hunter, Haoran Li, Chunjie Xiao, Hongkun Bao, Gang Wang, Jing Du
Publikováno v:
Journal of Neurochemistry. 158:358-372
Molecular abnormalities within the Glucocorticoid Receptor (GR) stress signaling pathway involved in dysfunction of mitochondria and confer vulnerability to stress related psychiatric disorders. Bcl-2 associated athanogene (Bag-1) is a target for the
Autor:
Xinlin Chen, Yan Luan, Yu-mei Tian, Y. Liu, Li Wang, Zhichao Zhang, Haixia Lu, Yong Liu, Xiaoyan Zheng, Lingyu Zhao, Jianshui Zhang
Publikováno v:
Journal of Neurochemistry. 156:465-480
Neural stem/progenitor cells (NSPCs) persist in the mammalian subventricular zone throughout life, where they can be activated in response to physiological and pathophysiological stimuli. A recent study indicates metabotropic glutamate receptor 4 (mG
Autor:
Rhayra Xavier do Carmo Silva, Denis B. Rosemberg, Gabriela Cristini Vidal Gomes, Maryana Pereira Pyterson, Caio Maximino, Monica Lima-Maximino, Sueslene Prado Rocha, Anderson Manoel Herculano
Publikováno v:
Journal of Neurochemistry. 153:495-509
Current theories on the role of serotonin (5-HT) in vertebrate defensive behavior suggest that this monoamine increases anxiety but decreases fear, by acting at different levels of the neuroaxis. This paradoxical, dual role of 5-HT suggests that a se
Autor:
Almudena Albillos, Juan Passas, J. Michael McIntosh, Arik J. Hone, Cristina de Castro-Guerín, Lola Rueda-Ruzafa, Jesús Blázquez, Carmen González-Enguita
Publikováno v:
Journal of Neurochemistry. 140:37-52
Varenicline is a nicotinic acetylcholine receptor (nAChR) agonist used to treat nicotine addiction but a live debate persists concerning its mechanism of action in reducing nicotine consumption. Although initially reported as α4β2-selective, vareni
Autor:
Antonio G. García, Angela López-Gil, Carmen Martínez-Ramírez, Enrique Calvo-Gallardo, Iago Méndez-López, Juan Fernando Padín
Publikováno v:
Journal of Neurochemistry. 139:722-736
Adrenal chromaffin cells (CCs) have been used extensively in studies aimed at revealing the intricacies of the Ca2+ -dependent early and late steps of regulated exocytosis. They have also served as invaluable models to study the kinetics of single-ve
Autor:
Hatsumi Yoshiki, Takanobu Taniguchi, Ikunobu Muramatsu, Matomo Nishio, Junsuke Uwada, Kiyonao Sada, Takayoshi Masuoka
Publikováno v:
Journal of Neurochemistry. 139:566-575
Functional acetylcholine receptors (AChRs) were recently demonstrated to exist not only in the plasma membrane but also intracellularly in brain tissues. In order to activate intracellular AChRs, endogenous hydrophilic ACh must cross the plasma membr
Autor:
Alexander A. Mongin, Kenneth R. Norman, Nina Martino, Zahra Ashkavand, Alejandro P. Adam, Corinne S. Wilson, Martin D. Bach
Publikováno v:
J Neurochem
Volume-regulated anion channel (VRAC) is a glutamate-permeable channel that is activated by physiological and pathological cell swelling and promotes ischemic brain damage. However, because VRAC opening requires cytosolic ATP, it is not clear if and
Publikováno v:
JOURNAL OF NEUROCHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
The glutamate-nitric oxide (NO)-cGMP pathway modulates some forms of learning. How glycine modulates this pathway is unclear. Glycine could modulate the pathway biphasically, enhancing its function through NMDA receptor activation or reducing it thro