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Publikováno v:
Journal of Neurochemistry. 60:2276-2284
Polyamines have pronounced effects on N-methyl-D-aspartate (NMDA) receptors in vitro and may be important modulators of NMDA receptor activity in vivo. There is considerable regional heterogeneity in the effects of polyamines on [3H]MK-801 binding in
Publikováno v:
Journal of Neurochemistry. 60:652-658
We have previously described the synthesis of bisphosphonate-containing inhibitors of inositol monophosphatase. In the present study, a more detailed examination of the in vitro and in vivo properties of one of these compounds, L-690,330, is describe
Publikováno v:
Journal of Neurochemistry. 60:204-211
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors
Autor:
Bart J. L. Eggen, Joseph Eichberg
Publikováno v:
Journal of Neurochemistry. 59:1467-1473
Evidence for the presence of phospholipase D activity in sciatic nerve was obtained by incubation of 32P-prelabeled nerve segments in the presence of ethanol and measurement of [32P]phosphatidylethanol (PEth) formation expressed as a fraction of tota
Publikováno v:
Journal of Neurochemistry. 59:610-615
In the presence of 1 mM spermine, accumulations of 3H labelled inositol phosphates elicited by quisqualate (100 microM) and 1-aminocyclopentane-trans-1,3-dicarboxylate (t-ACPD, 300 microM) were significantly enhanced by 21 and 26%, respectively, with
Autor:
Herbert Y. Meltzer, Junji Ichikawa
Publikováno v:
Journal of Neurochemistry. 58:2285-2291
The in vivo effects of amperozide, a novel atypical antipsychotic drug, on the release of dopamine (DA) and the output of its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), were investigated in the striatum and the nucleus accumbens of awake, fr
Autor:
Ling Song, Richard S. Jope
Publikováno v:
Journal of Neurochemistry. 58:2200-2206
Membranes prepared from rat brain regions were used to measure the receptor-coupled and/or guanine nucleotide-binding protein (G protein)-mediated hydrolysis of exogenous [3H]phosphatidylinositol ([3H]PI). Guanosine 5'-O-(3-thiotriphosphate) (GTP gam
Autor:
Bradley T. Hyman, Bruce R. Rosen, M. Flint Beal, Emmanuel Brouillet, Bruce G. Jenkins, Elsdon Storey, Joanne M. Miller
Publikováno v:
Journal of Neurochemistry. 58:1975-1978
The effects of 1-methyl-4-phenylpyridinium (MPP+) were studied in rat striatum. Using freeze-clamp, microwave, and water-suppressed proton chemical shift magnetic resonance imaging techniques, MPP+ resulted in marked increases in lactate and a deplet
Publikováno v:
Journal of Neurochemistry. 58:1246-1249
We have tested if inhibition of protein kinase C is able to prevent and/or to restore the decrease of Na+,K(+)-ATPase activity in the sciatic nerve of alloxan-induced diabetic mice. Mice were made diabetic by subcutaneous injection of 200 mg of allox
Publikováno v:
Journal of neurochemistry. 111(3)
In a previous study we showed that pharmacological blockade of the neurokinin-1 receptors attenuated the methamphetamine (METH)-induced toxicity of the striatal dopamine terminals. In the present study we examined the role of the neurokinin-1 recepto