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Autor:
Caroline E. Bass, Megan Vik, Caitlin Szalkowski, Jinwoo Park, Ken T. Wakabayashi, Rohan V. Bhimani
Publikováno v:
J Neurochem
Methamphetamine (METH) is a potent psychostimulant that exerts many of its physiological and psychomotor effects by increasing extracellular dopamine (DA) concentrations in limbic brain regions. While several studies have focused on how potent, neuro
Autor:
Shaolei Luo, Bruce S. McEwen, Yangyang Hou, Peixiong Yuan, Yue Jia, Husseini K. Manji, Lei Feng, Yaping Zhang, Richard G. Hunter, Haoran Li, Chunjie Xiao, Hongkun Bao, Gang Wang, Jing Du
Publikováno v:
Journal of Neurochemistry. 158:358-372
Molecular abnormalities within the Glucocorticoid Receptor (GR) stress signaling pathway involved in dysfunction of mitochondria and confer vulnerability to stress related psychiatric disorders. Bcl-2 associated athanogene (Bag-1) is a target for the
Autor:
Almudena Albillos, Juan Passas, J. Michael McIntosh, Arik J. Hone, Cristina de Castro-Guerín, Lola Rueda-Ruzafa, Jesús Blázquez, Carmen González-Enguita
Publikováno v:
Journal of Neurochemistry. 140:37-52
Varenicline is a nicotinic acetylcholine receptor (nAChR) agonist used to treat nicotine addiction but a live debate persists concerning its mechanism of action in reducing nicotine consumption. Although initially reported as α4β2-selective, vareni
Autor:
Antonio G. García, Angela López-Gil, Carmen Martínez-Ramírez, Enrique Calvo-Gallardo, Iago Méndez-López, Juan Fernando Padín
Publikováno v:
Journal of Neurochemistry. 139:722-736
Adrenal chromaffin cells (CCs) have been used extensively in studies aimed at revealing the intricacies of the Ca2+ -dependent early and late steps of regulated exocytosis. They have also served as invaluable models to study the kinetics of single-ve
Autor:
Hatsumi Yoshiki, Takanobu Taniguchi, Ikunobu Muramatsu, Matomo Nishio, Junsuke Uwada, Kiyonao Sada, Takayoshi Masuoka
Publikováno v:
Journal of Neurochemistry. 139:566-575
Functional acetylcholine receptors (AChRs) were recently demonstrated to exist not only in the plasma membrane but also intracellularly in brain tissues. In order to activate intracellular AChRs, endogenous hydrophilic ACh must cross the plasma membr
Autor:
Alicia R. Locker, Kimberly A. Kelly, Stephen M. Lasley, James P. O'Callaghan, Diane B. Miller
Publikováno v:
Journal of Neurochemistry
Gulf War Illness (GWI) is a multi‐symptom disorder with features characteristic of persistent sickness behavior. Among conditions encountered in the Gulf War (GW) theater were physiological stressors (e.g., heat/cold/physical activity/sleep depriva
Publikováno v:
Journal of Neurochemistry. 131:432-443
Drugs acting at the serotonin-2C (5-HT2C) receptor subtype have shown promise as therapeutics in multiple syndromes including obesity, depression, and Parkinson's disease. While it is established that 5-HT2C receptor stimulation inhibits DA release,
Autor:
Alessandro Tagliamonte, Barbara Danielli, Silvia Grappi, Giovanna Marchese, Carla Gambarana, Maria Graziella De Montis, Simona Scheggi
Publikováno v:
Journal of Neurochemistry. 112:531-541
In non-food-deprived rats a palatable meal induces a transient increase in dopamine output in the prefrontal cortex and nucleus accumbens shell and core; habituation to this response develops with a second palatable meal, selectively in the shell, un
Publikováno v:
Journal of Neurochemistry. 109:1272-1284
Repeated nicotine administration induces tyrosine hydroxylase (TH) mRNA in rat midbrain. In this study we investigate the mechanisms responsible for this response using two models of midbrain dopamine neurons, rat ventral midbrain slice explant cultu
Publikováno v:
Journal of Neurochemistry. 107:1369-1381
We have previously demonstrated that adenosine controls the release of catecholamines (CA) from carotid body (CB) acting on A2B receptors. Here, we have tested the hypothesis that the control is exerted via an interaction between adenosine A2B and do