Zobrazeno 1 - 10
of 1 089
pro vyhledávání: '"Lipids"'
Autor:
Shoichi Kinoshita, Taisuke Tomita, Yoshitake Sano, Junken Aoki, Takaomi C. Saido, Kazunori Kikuchi, Yuriko Sobu, Shunji Natori, Kuniyuki Kano, Toshiharu Suzuki, Hidenori Taru, Hiroto Komano, Saori Hata, Haruka Saito, Takashi Saito
Publikováno v:
Journal of Neurochemistry. 159:603-617
Two common conjugated linoleic acids (LAs), cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA), exert various biological activities. However, the effect of CLA on the generation of neurotoxic amyloid-β (Aβ) protein remains uncl
Publikováno v:
Journal of Neurochemistry. 159:343-377
High-density lipoproteins (HDL) are a heterogeneous class of molecules whose main function is to remove excess cholesterol through a mechanism called reverse transport, in which cholesterol is transported from peripheral organs and from arterial foam
Autor:
Laura Mauri, Margherita Maggioni, Elena Chiricozzi, Maria Fazzari, Diego Yuri Pomè, Sandro Sonnino, Giulia Lunghi, Nicoletta Loberto, Riccardo Casellato, Erika Di Biase
Publikováno v:
Journal of Neurochemistry. 149:231-241
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface. To study the TrkA-GM1 interaction, we synt
Publikováno v:
Journal of Neurochemistry, 156(5). Blackwell Publishing Ltd
Journal of Neurochemistry
Journal of Neurochemistry
Remyelination is a regenerative process that is essential to recover saltatory conduction and to prevent neurodegeneration upon demyelination. The formation of new myelin involves the differentiation of oligodendrocyte progenitor cells (OPCs) toward
Autor:
Marcelo Einicker-Lamas, Luiz Henrique Medeiros Geraldo, Flavia Regina Souza Lima, Rackele Ferreira do Amaral, Fabio A. Mendes, Tania Cristina Leite de Sampaio e Spohr
Publikováno v:
Journal of Neurochemistry. 156:499-512
Glioblastomas (GBMs) are highly aggressive primary brain tumors characterized by cellular heterogeneity, insensitivity to chemotherapy and poor patient survival. Lysophosphatidic acid (LPA) is a lysophospholipid that acts as a bioactive signaling mol
Publikováno v:
Journal of Neurochemistry. 148:600-611
Ceramide, sphingomyelin, and glycosphingolipids (both neutral and acidic) are characterized by the presence in the lipid moiety of an aliphatic base known as sphingosine. Altogether, they are called sphingolipids and are particularly abundant in neur
Autor:
Sandro Sonnino, Luca Palazzolo, Nicoletta Loberto, Ivano Eberini, Diego Yuri Pomè, Chiara Parravicini, Elena Chiricozzi, Erika Di Biase, Margherita Maggioni
Publikováno v:
Journal of Neurochemistry. 143:645-659
GM1 ganglioside (II3 NeuAc-Gg4 Cer) is known to promote neurite formation in neuroblastoma cells by activating TrkA-MAPK pathway. The molecular mechanism by which GM1 is involved in the neurodifferentiation process is still unknown, however, in vitro
Autor:
James Melrose
Publikováno v:
Journal of Neurochemistry. 149:170-194
Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties. In the human body, the cornea and the
Autor:
Karunya K. Kandimalla, Stephanie Ortiz-Valle, Dustin Chernick, Ling Li, Angela Jeong, G. William Rebeck, Suresh Kumar Swaminathan
Publikováno v:
Journal of Neurochemistry. 147:647-662
The apolipoprotein E (apoE) e4 allele is the primary genetic risk factor for late-onset Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once secreted from these cells, apoE binds lipids and forms high-density lipoprot
Autor:
Steffany A. L. Bennett, Hongbin Xu, Alexandre P. Blanchard, Hui Liu, Matthew W. Granger, Caitlin F. Fowler, Samantha P. M. Sherman, Matthew W. Taylor, Weidong Le
Publikováno v:
Journal of Neurochemistry. 149:499-517
Changes in glycerophosphocholine metabolism are observed in Alzheimer's disease; however, it is not known whether these metabolic disruptions are linked to cognitive decline. Here, using unbiased lipidomic approaches and direct biochemical assessment