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Publikováno v:
Journal of Neurochemistry. 159:512-524
Studies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine-induced abnormal pain sensations. However, the role of FMRP in
Autor:
Marc-André Clément, Mélanie Tremblay, Cristina R. Bosoi, Chantal Bémeur, Mariana M Oliveira, Christopher F. Rose
Publikováno v:
Journal of Neurochemistry. 157:561-573
Hepatic encephalopathy (HE) is a debilitating neurological complication of cirrhosis. By definition, HE is considered a reversible disorder, and therefore HE should resolve following liver transplantation (LT). However, persisting neurological compli
Autor:
Carme Auladell, Blanca López, Rubén Darío Castro-Torres, Oriol Busquets, Ester Verdaguer, Jaume Folch, Patricia Regina Manzine, Jordi Olloquequi, Àuria Eritja, Antoni Camins, Manuel Vázquez-Carrera, Miren Ettcheto
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Insulin resistance has negative consequences on the physiological functioning of the nervous system. The appearance of type 3 diabetes in the brain leads to the development of the sporadic form of Alzheimer's disease. The c-Jun N-terminal kinases (JN
Autor:
Roland A. Bender, Michael K. E. Schäfer, Gabriele M. Rune, Jana Westerhorstmann, Tobias Hirnet, Christina Gölz, Matthias Schmidt, Florian Paul Kirchhoff
Publikováno v:
Journal of neurochemistry. 150(2)
Clinical and animal studies have revealed sex-specific differences in histopathological and neurological outcome after traumatic brain injury (TBI). The impact of perioperative administration of sex steroid inhibitors on TBI is still elusive. Here, w
Publikováno v:
Journal of Neurochemistry. 136:859-870
Incretin-related therapy was found to be beneficial for experimental diabetic neuropathy, but its mechanism is obscure. The purpose of this study is to explore the mechanism through which dipeptidyl peptidase IV inhibitor, vildagliptin (VG), influenc
Publikováno v:
Journal of Neurochemistry. 135:301-308
Increasing evidence has shown that type 2 diabetes (T2D) is a risk factor for Alzheimer's disease. Neurofibrillary tangles, which consist of hyperphosphorylated tau and misfolded microtubules, is one of the neuropathological hallmarks of Alzheimer's
Autor:
Cross Jh, Hughes Sd, Iain P. Hargreaves, Maura O’Donnell, Marta Kanabus, Simon Heales, Tricia Rutherford, Glenn Anderson, Shamima Rahman, Simon Eaton
Publikováno v:
Journal of Neurochemistry. 129:426-433
The Ketogenic diet (KD) is an effective treatment with regards to treating pharmaco-resistant epilepsy. However, there are difficulties around compliance and tolerability. Consequently, there is a need for refined/simpler formulations that could repl
Publikováno v:
Journal of Neurochemistry. 121:700-704
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in norepinephrine synthesis, and its expression and activity are regulated by many factors in sympathetic neurons. Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decr
Autor:
Yongqin Xu, Bhagat Singh, Jose A. Martinez, Vandana Singh, Douglas W. Zochodne, Anand Krishnan, Todd McLaughlin
Publikováno v:
Journal of Neurochemistry. 121:263-276
J. Neurochem. (2012) 121, 263–276. Abstract Insulin offers trophic support through receptors expressed widely on peripheral neurons. In this work, we studied whether peripheral sensory neurons demonstrate resistance to its trophic properties, a pro
Publikováno v:
Journal of Neurochemistry. 118:658-667
Targeting hyperphosphorylated tau by immunotherapy is emerging as a promising approach to treat tauopathies such as Alzheimer's disease and frontotemporal dementia. We have previously reported that active tau immunization clears tau aggregates from t