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Autor:
Hatem Soliman, Hyo S. Han, John A. Arrington, Nam D. Tran, Timothy J. Robinson, Peter A. Forsyth, Solmaz Sahebjam, Thrisha K Potluri, Kamran Ahmed, Nicholas B Figura, James K. Liu, Homan Mohammadi, Daniel E. Oliver, H. Michael Yu, Arnold B. Etame
Publikováno v:
Journal of neuro-oncology. 144(3)
Cyclin-dependent kinase (CDK) 4/6 inhibitors are becoming increasingly utilized in the setting of advanced, hormone receptor (HR+) positive breast cancer. Pre-clinical data suggests a potential synergy between radiation therapy (RT) and CDK4/6 inhibi
Autor:
L. Burt Nabors, Jaishri O. Blakeley, Jeffrey G. Supko, Gary Emmons, Stuart A. Grossman, Myrna R. Rosenfeld, David M. Peereboom, Ignacio Garcia Ribas, Tom Mikkelsen, Serena Desideri, Xiaobu Ye, Andrew S. Chi
Publikováno v:
Journal of Neuro-Oncology. 125:123-131
Iniparib is a prodrug that converts to highly reactive cytotoxic metabolites intracellularly with activity in preclinical glioma models. We investigated the maximum tolerated dose (MTD) of iniparib with monthly (m) and continuous (c) temozolomide (TM
Autor:
Tania Fleitas, María E. Martín, Virtudes Vila, Edelmiro Reganon, Vicenta Martínez-Sales, Gaspar Reynes, Antonio Parada
Publikováno v:
JOURNAL OF NEURO-ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Inflammation, angiogenesis, and coagulation are linked to the development of cancer. In glioblastoma, microvascular proliferation is a hallmark, and lymphocytic infiltration is a common finding. Thromboses are frequent in patients with glioblastoma.
Autor:
Akira Matsumura, Shingo Takano, Hiroshi Kamiyama, Eiichi Ishikawa, Ryota Mashiko, Satoru Osuka
Publikováno v:
Journal of neuro-oncology. 99(2):177-185
Irinotecan (CPT-11) has shown emerging promise in the treatment of malignant gliomas. It is believed the mechanism of action of irinotecan is to sensitize glioma cells to the cytotoxic action of radiation therapy and alkylating agents. However, clini
Autor:
Hidehisa Horiguchi, Toshiyuki Okazaki, Hiroyoshi Watanabe, Shinji Nagahiro, Teruyoshi Kageji, Takanori Hirose, Kazuhito Matsuzaki, Toshihiro Ohnishi
Publikováno v:
Journal of Neuro-Oncology. 94:431-437
We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion. Head- and spinal magnetic resonance imaging (MRI) showe
Autor:
Dorcas Fulton, P. A. Tang, Gloria Roldán, Wilson Roa, J. G. Cairncross, Peter A. Forsyth, Amy P. Murtha, P. M. A. Brasher
Publikováno v:
Journal of Neuro-Oncology. 78:311-316
To determine the response rate, time to disease progression, survival, and toxicity of intravenous carboplatin and chronic oral high-dose tamoxifen in patients with recurrent malignant gliomas. Patients with histological confirmation of recurrent mal
Publikováno v:
Journal of Neuro-Oncology. 111:87-89
Bevacizumab (Avastin , Genentech Inc., San Francisco, CA) was granted accelerated approval from the Food and Drug Administration as single agent treatment of recurrent glioblastoma (GB) based on the high radiologic response rate demonstrated in two p
Autor:
Karl Rössler, Slavc I, Mehmet Günes, Thomas Czech, Wolfgang Dietrich, Konrad Pillwein, Elisabeth Schuller, Johannes A. Hainfellner, Daniela Prayer, Jutta Falger, Karin Dieckmann
Publikováno v:
Journal of Neuro-Oncology. 64:239-247
Treatment options for leptomeningeal disseminated brain tumors are limited by the lack of effective drugs for intrathecal therapy of non-hematologic malignancies. We report on our experience with an intraventricular therapy consisting of mafosfamide,
Publikováno v:
Journal of Neuro-Oncology. 106:427-429
While growth factors exist to support patients with treatment-induced neutropenia and anemia, treatment-induced thrombocytopenia remains a problem and often causes treatment delays and dose reductions and requires platelet transfusions. Toxicities su
Autor:
Daizo Yoshida, Akira Teramoto, Yuichi Sugisaki, Kunihiro Watanabe, Masahiro Noha, Hiroshi Takahashi
Publikováno v:
Journal of Neuro-Oncology. 54:23-29
Estramustine phosphate (EMP) is an anti-microtubule agent that induces apoptosis of glioma cells. We investigated whether EMP caused apoptosis through the alkylating effect of its nitrogen mustard component or by phosphorylation of bcl-2 like other a