Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Theodore R. Holman"'
Autor:
Eric K. Hoobler, Karen Tenney, Sarah J. Robinson, Theodore R. Holman, Michelle Riener, Frederick A. Valeriote, Phillip Crews, Steven T. Loveridge
Publikováno v:
Journal of Natural Products. 72:1857-1863
Enzyme screening of crude sponge extracts prioritized a 2005 Papua New Guinea collection of Hyrtios sp. for further study. The MeOH extract contained puupehenone and four puupehenone analogues (1, 2, 3, 5, and 7) along with a new diastereomer, 20-epi
Autor:
Karen Tenney, Jennifer E. Compton, Claudia M. Boot, Phillip Crews, Theodore R. Holman, Nadine C. Gassner, Craig M. Tamble, R. Scott Lokey
Publikováno v:
Journal of natural products. 70(10)
A new compound of mixed polyketide synthase-nonribosomal peptide synthetase (PKS/NRPS) origin, 11- O-methylpseurotin A ( 1), was identified from a marine-derived Aspergillus fumigatus. Bioassay-guided fractionation using a yeast halo assay with wild-
Publikováno v:
Journal of natural products. 67(8)
Two new phakellin alkaloids, (-)-7-N-methyldibromophakellin (14) and (-)-7-N-methylmonobromophakellin (15), were isolated from an Agelas sp. sponge, collected near Wewak, Papua New Guinea. Inhibition assays employing both 12- and 15-human lipoxygenas
Autor:
Theodore R. Holman, Chad C. Stessman, Jon Clardy, Phillip Crews, Christopher P. Loo, Tyler A. Johnson, Emil B. Lobkovsky, Stephanie Whitman, Taro Amagata
Publikováno v:
Journal of natural products. 66(2)
To sharpen the search for new lipoxygenase inhibitors, we designed a screen to probe for both potency and selectivity. The assay utilized 12-human (12-HLO), 15-human (15-HLO), and 15-soybean (15-SLO) lipoxygenases. The IC(50) value data obtained prov